Latest Issue

“A new study introduces its research progress in the field of thrombocytopenia. Experts established a mouse model of radiation injury-induced thrombocytopenia and explored the underlying pathogenic mechanism, which provides solutions to solve thrombosis problems.”

“In the field of liver cancer research, this study investigates how FBXL6 regulates KRAS and KRASG12D activity in hepatocellular carcinoma. Expert established the FBXL6/KRAS/ERK/mTOR/PRELID2/ROS axis, which provides a potential therapeutic strategy to treat aggressive liver cancer.”

“Reporting on the latest research, experts have integrated up-to-date findings on endoplasmic reticulum stress in the pathogenesis of degenerative musculoskeletal diseases, laying a foundation for the construction of ER stress modulators in clinical trials.”

“In the field of cancer immunotherapy, researchers have summarized the epigenetic mechanisms leading to T cell exhaustion in the tumor microenvironment and discussed the therapeutic potential of targeting epigenetic regulators for immunotherapies. This lays a foundation for the construction of treatment paradigms involving immunostimulatory agents and epigenetic therapies.”

“Nuclear receptor NR1D1, a key transcription factor in the circadian clock, plays a crucial role in regulating downstream target genes involved in autophagy, immunity, inflammation, metabolism, and aging. This review highlights the latest milestones in NR1D1 ligand research, which may pave the way for their clinical application in treating diverse organ injury-related diseases.”

“Electroencephalography (EEG), a non-invasive measurement method for brain activity, has garnered significant interest in scientific research and medical fields due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals. This article reviews the types of EEG signals, multiple EEG signal analysis methods, and their applications in neuroscience and diagnosing neurological diseases. It introduces three types of EEG signals and describes five main directions for EEG analysis methods, along with different sub-methods and effect evaluations for solving the same problem. The article emphasizes the application scenarios of different EEG analysis methods and distinguishes the advantages and disadvantages of similar methods, assisting researchers in selecting suitable EEG analysis methods based on their research objectives and providing references for subsequent research.”

“Reporting on the latest advancements in congenital hydrocephalus research, this review delves into the genetic underpinnings of the condition, identifying pertinent genes and potential new targets for treatment. Expert researchers have established a deeper understanding of CH-related genes, which lays a foundation for the construction of more precise diagnostic and therapeutic strategies.”

“In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.”