Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

Ze-Qin Wen; Jun Lin; Wen-Qing Xie; Yun-Han Shan; Ge-Hua Zhen; Yu-Sheng Li

doi:10.1186/s40779-023-00485-5

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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

REVIEW | Updated：2025-12-13

- Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
- Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
- “在报告最新研究时，专家们整合了内质网应激在退行性肌肉骨骼疾病发病机制中的最新发现，为在临床试验中构建内质网应激调节剂奠定了基础。”
- MMR 2024年11卷第6期页码：839-862
- Affiliations：
  
  1.Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China
  2.Xiangya School of Medicine, Central South University, Changsha 410013, China
  3.Department of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215001, China
  4.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
  5.Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
  6.Department of Orthopaedic Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
- Author bio：
  
  *gzhen1@jhmi.edu;
  liyusheng@csu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(92268115;82072506;81874030;82172387;82372371;82371989);the Science and Technology Innovation Program of Hunan Province(2021RC3025);the Natural Science Foundation of Jiangsu Province(BK20230066);the Suzhou Science and Technology Development Plan(SKY2023035;SZM2023008);the Gusu Health Talents Program(GSWS2020023);the Innovation Project for Postgraduate Students of Central South University(1053320221391;1053320231273)
- DOI：10.1186/s40779-023-00485-5
  中图分类号：
- 纸质出版：2024-12
- Accepted：
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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases[J]. MMR, 2024,11(6):839-862.

Cite this article as: Wen ZQ, Lin J, Xie WQ, Shan YH, Zhen GH, Li YS. Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases. Mil Med Res. 2023;10(1):54.
Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases[J]. MMR, 2024,11(6):839-862. DOI： 10.1186/s40779-023-00485-5.

Cite this article as: Wen ZQ, Lin J, Xie WQ, Shan YH, Zhen GH, Li YS. Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases. Mil Med Res. 2023;10(1):54. DOI： 10.1186/s40779-023-00485-5.

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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases

DOI：10.1186/s40779-023-00485-5