Targeting NR1D1 in organ injury: challenges and prospects

Zi-Yin Zhang-Sun; Xue-Zeng Xu; Germaine Escames; Wang-Rui Lei; Lin Zhao; Ya-Zhe Zhou; Ye Tian; Ya-Nan Ren; Darío Acuña-Castroviejo; Yang Yang

doi:10.1186/s40779-023-00495-3

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Targeting NR1D1 in organ injury: challenges and prospects

REVIEW | Updated：2025-12-13

- Targeting NR1D1 in organ injury: challenges and prospects
- Targeting NR1D1 in organ injury: challenges and prospects
- “核受体NR1D1是昼夜节律钟中的关键转录因子，在调节自噬、免疫、炎症、代谢和衰老等下游靶基因方面起着至关重要的作用。本综述重点介绍了NR1D1配体研究的最新里程碑，这可能为其在治疗各种器官损伤相关疾病的临床应用铺平道路。”
- MMR 2024年11卷第6期页码：887-906
- Affiliations：
  
  1.Department of Cardiology, Northwest University First Hospital, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  2.Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China
  3.Department of Cardiovascular Surgery, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  4.Biomedical Research Center, Department of Physiology, Faculty of Medicine, Institute of Biotechnology, Technological Park of Health Sciences, University of Granada, 18016 Granada, Spain
  5.Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Ibs.Granada, San Cecilio University Hospital, 18016 Granada, Spain
  6.UGC of Clinical Laboratories, San Cecilio Clinical University Hospital, 18016 Granada, Spain
- Author bio：
  
  *dacuna@ugr.es;
  yang200214yy@nwu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82070422;82200330);the China Postdoctoral Science Foundation(2023T160526;2022M722571);the Research Plan Project of Shaanxi Institute of Basic Science(22JHQ053);the High-end Foreign Expert Introduction Program of National Science and Technology(G2022040014L);the Qinchuangyuan Traditional Chinese Medicine Innovation Research and Development Transformation Project(2022-QCYZH-036)
- DOI：10.1186/s40779-023-00495-3
  中图分类号：
- 纸质出版：2024-12
- Accepted：
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Targeting NR1D1 in organ injury: challenges and prospects[J]. MMR, 2024,11(6):887-906.

Cite this article as: Zhang-Sun ZY, Xu XZ, Escames G, Lei WR, Zhao L, Zhou YZ, et al. Targeting NR1D1 in organ injury: challenges and prospects. Mil Med Res. 2023;10(1):62.
Targeting NR1D1 in organ injury: challenges and prospects[J]. MMR, 2024,11(6):887-906. DOI： 10.1186/s40779-023-00495-3.

Cite this article as: Zhang-Sun ZY, Xu XZ, Escames G, Lei WR, Zhao L, Zhou YZ, et al. Targeting NR1D1 in organ injury: challenges and prospects. Mil Med Res. 2023;10(1):62. DOI： 10.1186/s40779-023-00495-3.

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Targeting NR1D1 in organ injury: challenges and prospects

Targeting NR1D1 in organ injury: challenges and prospects

DOI：10.1186/s40779-023-00495-3