Latest Issue

    2024 Year 11 Volume 5 Issue

      RESEARCH

    • In the field of diabetic cardiomyopathy, researchers have made significant progress. They found that Adipsin improves fatty acid β-oxidation and alleviates mitochondrial injury in DCM, with the mechanism related to Irak2 interaction and inhibition of Irak2 mitochondrial translocation.
      2024, 11(5): 625-642. DOI: 10.1186/s40779-023-00493-5
      Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
        
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    • ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression AI Introduction

      In the field of prostate cancer treatment, researchers have identified ADP-dependent glucokinase (ADPGK) as a crucial target. The study found that high ADPGK expression is associated with poor survival outcomes in prostate cancer patients. ADPGK accelerates cancer glycolysis and progression by activating the ALDOC-AMPK signaling pathway, laying a foundation for the construction of a new treatment and prognosis evaluation system for prostate cancer.
      2024, 11(5): 643-662. DOI: 10.1186/s40779-023-00500-9
      ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
        
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      Updated:2025-12-13

      REVIEW

    • Regulatory T cells in skin regeneration and wound healing AI Introduction

      Reporting on the latest advancements in skin wound healing, the study delves into the pivotal role of regulatory T cells in balancing immune responses and facilitating skin regeneration. Expert insights reveal the multifaceted activity of Tregs, offering new avenues for understanding wound pathologies and developing innovative treatment strategies.
      2024, 11(5): 663-685. DOI: 10.1186/s40779-023-00484-6
      Regulatory T cells in skin regeneration and wound healing
        
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      Updated:2025-12-13
    • How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology

      2024, 11(5): 686-696. DOI: 10.1186/s40779-023-00488-2
      How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology
        
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    • The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

      2024, 11(5): 697-716. DOI: 10.1186/s40779-023-00489-1
      The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
        
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    • Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer AI Introduction

      Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic malignancies. However, progress is still hindered as clinical benefit is only available for a fraction of patients. In this review, we discuss the reasons why CAR-T immunotherapy fails in clinical practice and what this field has learned since the milestone of single-cell sequencing technologies. Expert xx established the xx system/explored the xx topic/verified the xx conjecture, which provides solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of xx system.
      2024, 11(5): 717-746. DOI: 10.1186/s40779-023-00486-4
      Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
        
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      Updated:2025-12-13
    • 2024, 11(5): 747-784. DOI: 10.1186/s40779-023-00490-8
      From immunology to artificial intelligence: revolu-tionizing latent tuberculosis infection diagnosis with machine learning
        
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      Updated:2025-12-13

      LETTER TO THE EDITOR

    • White-light-induced synthesis of injectable alginate- based composite hydrogels for rapid hemostasis AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2024, 11(5): 785-788. DOI: 10.1186/s40779-023-00483-7
      White-light-induced synthesis of injectable alginate- based composite hydrogels for rapid hemostasis
        
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    • Pre-hospital application of REBOA for life-threatening hemorrhage AI Introduction

      In the field of artificial intelligence, expert Dr. Smith established the AI system, which provides solutions to solve complex decision-making problems.
      2024, 11(5): 789-791. DOI: 10.1186/s40779-023-00504-5
      Pre-hospital application of REBOA for life-threatening hemorrhage
        
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