Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

Dian Xiong; Lu Zhang; Zhi-Jun Sun

doi:10.1186/s40779-023-00496-2

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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

REVIEW | Updated：2025-12-13

- Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
- Targeting the epigenome to reinvigorate T cells for cancer immunotherapy
- “在癌症免疫治疗领域，研究人员总结了导致肿瘤微环境中T细胞耗竭的表观遗传学机制，并讨论了靶向表观遗传学调节因子用于免疫治疗的治疗潜力。这为构建涉及免疫刺激剂和表观遗传疗法的治疗范式奠定了基础。”
- MMR 2024年11卷第6期页码：863-886
- Affiliations：
  
  1.State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430079, China
  2.Department of Oral Maxillofacial-Head Neck Oncology, School and and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
- Author bio：
  
  *luzhang2012@whu.edu.cn;
  sunzj@whu.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82273202;82370948;82072996;82170941);the Fundamental Research Funds for the Central Universities(2042022dx0003);the Hubei Province International Science and Technology Cooperation Project(2021EHB027);the National Key Research and Development Program(2022YFC2504200)
- DOI：10.1186/s40779-023-00496-2
  中图分类号：
- 纸质出版：2024-12
- Accepted：
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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy[J]. MMR, 2024,11(6):863-886.

Cite this article as: Xiong D, Zhang L, Sun ZJ. Targeting the epigenome to reinvigorate T cells for cancer immunotherapy. Mil Med Res. 2023;10(1):59.
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy[J]. MMR, 2024,11(6):863-886. DOI： 10.1186/s40779-023-00496-2.

Cite this article as: Xiong D, Zhang L, Sun ZJ. Targeting the epigenome to reinvigorate T cells for cancer immunotherapy. Mil Med Res. 2023;10(1):59. DOI： 10.1186/s40779-023-00496-2.

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Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

DOI：10.1186/s40779-023-00496-2