ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

Hang Xu; Yi-Fan Li; Xian-Yan-Ling Yi; Xiao-Nan Zheng; Yang Yang; Yan Wang; Da-Zhou Liao; Jia-Peng Zhang; Ping Tan; Xing-Yu Xiong; Xi Jin; Li-Na Gong; Shi Qiu; De-Hong Cao; Hong Li; Qiang Wei; Lu Yang; Jian-Zhong Ai

doi:10.1186/s40779-023-00500-9

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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

RESEARCH | Updated：2025-12-13

- ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
- ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
- “在前列腺癌症治疗领域，研究人员已确定ADP-依赖性葡萄糖激酶（ADPGK）为关键靶点。研究发现，ADPGK的高表达与前列腺癌症患者的不良生存结果有关。ADPGK通过激活ALDOC-AMPK信号通路，加速癌症糖酵解和进展，为构建新的癌症治疗和预后评估系统奠定基础。”
- MMR 2024年11卷第5期页码：643-662
- Affiliations：
  
  1.Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  2.Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  3.Animal Experimental Center, West China Hospital, Sichuan University, Chengdu 610041, China
  4.Research Core Facility, West China Hospital, Sichuan University, Chengdu 610041, China
- Author bio：
  
  *weiqiang@scu.edu.cn;
  wycleflue@scu.edu.cn;
  jianzhong.ai@scu.edu.cn
- Funds：
  
  the National Key Research and Development Plan(2023YFC3403200);the National Natural Science Foundation of China(82070784;81702536;81974099;82170785);the Science & Technology Department of Sichuan Province, China(2022JDRC0040;21GJHZ0246);the Young Investigator Award of Sichuan University 2017(2017SCU04A17);the Sichuan University-Panzhihua Science and Technology Cooperation Special Fund(2020CDPZH-4);the China Postdoctoral Science Foundation(2021M692306);the Post-Doctor Research Project of West China Hospital of Sichuan University(2021HXBH025)
- DOI：10.1186/s40779-023-00500-9
  中图分类号：
- 纸质出版：2024-10
- Accepted：
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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression[J]. MMR, 2024,11(5):643-662.

Cite this article as: Xu H, Li YF, Yi XYL, Zheng XN, Yang Y, Wang Y, et al. ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression. Mil Med Res. 2023;10(1):64.
ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression[J]. MMR, 2024,11(5):643-662. DOI： 10.1186/s40779-023-00500-9.

Cite this article as: Xu H, Li YF, Yi XYL, Zheng XN, Yang Y, Wang Y, et al. ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression. Mil Med Res. 2023;10(1):64. DOI： 10.1186/s40779-023-00500-9.

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ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression

DOI：10.1186/s40779-023-00500-9