The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
- MMR 2024年11卷第5期 页码：697-716
- Affiliations：
1.Department of Infectious Diseases, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
2.Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250000, China
3.Department of Cardiovascular Medicine, Henan Provincial Chest Hospital, Zhengzhou 450008, China
4.Department of Blood Collection, Xuchang Blood Center, Xuchang 461000, Henan, China
5.Nanchang University Queen Marry School, Nanchang 330036, China
- Author bio：
*xkyuanyq@zzu.edu.cn;
johnyuem@zzu.edu.cn;
fccrenzg@zzu.edu.cn
- Funds：This study was supported by the National Key Research and Development Program of China(2022YFC2303100);the Central Plains Talent Program-Central Plains Youth Top Talents, the Young and Middle-aged Academic Leaders of Henan Provincial Health Commission(HNSWJW-2022013);the Funding for Scientific Research and Innovation Team of the First Affiliated Hospital of Zhengzhou University(QNCXTD2023002;ZYCXTD2023002);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022001A;JNL-2022015B)
DOI：10.1186/s40779-023-00489-1
中图分类号：-
纸质出版：2024-10
- Accepted：
Scan QR Code
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives[J]. MMR, 2024,11(5):697-716.
Cite this article as: Li N, Wang L, Li L, Yang MZ, Wang QX, Bai XW, et al. The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives. Mil Med Res. 2023;10(1):51.
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives[J]. MMR, 2024,11(5):697-716. DOI： 10.1186/s40779-023-00489-1.
Cite this article as: Li N, Wang L, Li L, Yang MZ, Wang QX, Bai XW, et al. The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives. Mil Med Res. 2023;10(1):51. DOI： 10.1186/s40779-023-00489-1.
摘要
Abstract
Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population ages and chronic disease survival rates increase; however
the mechanisms are not entirely clarified. It is gaining awareness that alterations in the assembly
structure
and dynamics of gut microbiota are intimately engaged in the AF progression. Owing to advancements in next-generation sequencing technologies and computational strategies
researchers can explore novel linkages with the genomes
transcriptomes
proteomes
and metabolomes through parallel meta-omics approaches
rendering a panoramic view of the culture-independent microbial investigation. In this review
we summarized the evidence for a bidirectional correlation between AF and the gut microbiome. Furthermore
we proposed the concept of "gut-immune-heart" axis and addressed the direct and indirect causal roots between the gut microbiome and AF. The intricate relationship was unveiled to generate innovative microbiota-based preventive and therapeutic interventions
which shed light on a definite direction for future experiments.
关键词
Keywords
references
Kim JE , Li B , Fei L , Horne R , Lee D , Loe AK , et al . Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development . Immunity . 2022 ; 55 ( 12 ): 2300 - 17.e6 .
Xiao W , Su J , Gao X , Yang H , Weng R , Ni W , et al . The microbiota-gutbrain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids . Microbiome . 2022 ; 10 ( 1 ): 62 .
Manor O , Dai CL , Kornilov SA , Smith B , Price ND , Lovejoy JC , et al . Health and disease markers correlate with gut microbiome composition across thousands of people . Nat Commun . 2020 ; 11 ( 1 ): 5206 .
Cui GY , Rao BC , Zeng ZH , Wang XM , Ren T , Wang HY , et al . Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up . Mil Med Res . 2022 ; 9 ( 1 ): 32 .
Rao BC , Zhang GZ , Zou YW , Ren T , Ren HY , Liu C , et al . Alterations in the human oral microbiome in cholangiocarcinoma . Mil Med Res . 2022 ; 9 ( 1 ): 62 .
Li LY , Han J , Wu L , Fang C , Li WG , Gu JM , et al . Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats . Mil Med Res . 2022 ; 9 ( 1 ): 12 .
Patti G , Lucerna M , Pecen L , Siller-Matula JM , Cavallari I , Kirchhof P , et al . Thromboembolic risk, bleeding outcomes and effect of different antithrombotic strategies in very elderly patients with atrial fibrillation: a sub-analysis from the PREFER in AF (PREvention oF thromboembolic events-European Registry in Atrial Fibrillation) . J Am Heart Assoc . 2017 ; 6 ( 7 ): e005657 .
Ngo L , Woodman R , Denman R , Walters TE , Yang IA , Ranasinghe I . Longitudinal risk of death, hospitalizations for atrial fibrillation, and cardiovascular events following catheter ablation of atrial fibrillation: a cohort study . Eur Heart J Qual Care Clin Outcomes . 2023 ; 9 ( 2 ): 150 – 60 .
Wang M , Xiong H , Lu L , Zhu T , Jiang H . Serum lipopolysaccharide is associated with the recurrence of atrial fibrillation after radiofrequency ablation by increasing systemic inflammation and atrial fibrosis . Oxid Med Cell Longev . 2022 ; 2022 : 2405972 .
Zhang Y , Zhang S , Li B , Luo Y , Gong Y , Jin X , et al . Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome . Cardiovasc Res . 2022 ; 118 ( 3 ): 785 – 97 .
Kong B , Fu H , Xiao Z , Zhou Y , Shuai W , Huang H . Gut microbiota dysbiosis induced by a high-fat diet increases susceptibility to atrial fibrillation . Can J Cardiol . 2022 ; 38 ( 12 ): 1962 – 75 .
Drapkina OM , Yafarova AA , Kaburova AN , Kiselev AR . Targeting gut microbiota as a novel strategy for prevention and treatment of hypertension, atrial fibrillation and heart failure: current knowledge and future perspectives . Biomedicines . 2022 ; 10 ( 8 ): 2019 .
Gawalko M , Agbaedeng TA , Saljic A , Muller DN , Wilck N , Schnabel R , et al . Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications . Cardiovasc Res . 2022 ; 118 ( 11 ): 2415 – 27 .
Lu D , Zou X , Zhang H . The relationship between atrial fibrillation and intestinal flora with its metabolites . Front Cardiovasc Med . 2022 ; 9 : 948755 .
Lagier JC , Khelaifia S , Alou MT , Ndongo S , Dione N , Hugon P , et al . Culture of previously uncultured members of the human gut microbiota by culturomics . Nat Microbiol . 2016 ; 1 : 16203 .
Pasolli E , Asnicar F , Manara S , Zolfo M , Karcher N , Armanini F , et al . Extensive unexplored human microbiome diversity revealed by over 150,000 genomes from metagenomes spanning age, geography, and lifestyle . Cell . 2019 ; 176 ( 3 ): 649 - 62.e20 .
Abubucker S , Segata N , Goll J , Schubert AM , Izard J , Cantarel BL , et al . Metabolic reconstruction for metagenomic data and its application to the human microbiome . PLoS Comput Biol . 2012 ; 8 ( 6 ): e1002358 .
Cambiaghi A , Ferrario M , Masseroli M . Analysis of metabolomic data: tools, current strategies and future challenges for omics data integration . Brief Bioinform . 2017 ; 18 ( 3 ): 498 – 510 .
Nicholson JK , Holmes E , Kinross J , Burcelin R , Gibson G , Jia W , et al . Hostgut microbiota metabolic interactions . Science . 2012 ; 336 ( 6086 ): 1262 – 7 .
David LA , Maurice CF , Carmody RN , Gootenberg DB , Button JE , Wolfe BE , et al . Diet rapidly and reproducibly alters the human gut microbiome . Nature . 2014 ; 505 ( 7484 ): 559 – 63 .
Bikel S , Valdez-Lara A , Cornejo-Granados F , Rico K , Canizales-Quinteros S , Soberón X , et al . Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome . Comput Struct Biotechnol J . 2015 ; 13 : 390 – 401 .
Zhang X , Figeys D . Perspective and guidelines for metaproteomics in microbiome studies . J Proteome Res . 2019 ; 18 ( 6 ): 2370 – 80 .
Ali RO , Quinn GM , Umarova R , Haddad JA , Zhang GY , Townsend EC , et al . Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis . Nat Microbiol . 2023 ; 8 ( 1 ): 12 – 27 .
Mills RH , Dulai PS , Vazquez-Baeza Y , Sauceda C , Daniel N , Gerner RR , et al . Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity . Nat Microbiol . 2022 ; 7 ( 2 ): 262 – 76 .
Blanco-Miguez A , Fdez-Riverola F , Sanchez B , Lourenco A . Resources and tools for the high-throughput, multi-omic study of intestinal microbiota . Brief Bioinform . 2019 ; 20 ( 3 ): 1032 – 56 .
Weiss S , Van Treuren W , Lozupone C , Faust K , Friedman J , Deng Y , et al . Correlation detection strategies in microbial data sets vary widely in sensitivity and precision . ISME J . 2016 ; 10 ( 7 ): 1669 – 81 .
Chaudhary K , Poirion OB , Lu L , Garmire LX . Deep learning-based multiomics integration robustly predicts survival in liver cancer . Clin Cancer Res . 2018 ; 24 ( 6 ): 1248 – 59 .
Zuo K , Li J , Li K , Hu C , Gao Y , Chen M , et al . Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation . Gigascience . 2019 ; 8 ( 6 ): giz058 .
Zuo K , Li J , Wang P , Liu Y , Liu Z , Yin X , et al . Duration of persistent atrial fibrillation is associated with alterations in human gut microbiota and metabolic phenotypes . mSystems . 2019 ; 4 ( 6 ): e00422 – 519 .
Zuo K , Yin X , Li K , Zhang J , Wang P , Jiao J , et al . Different types of atrial fibrillation share patterns of gut microbiota dysbiosis . mSphere . 2020 ; 5 ( 2 ): e00071 .
Li J , Zuo K , Zhang J , Hu C , Wang P , Jiao J , et al . Shifts in gut microbiome and metabolome are associated with risk of recurrent atrial fibrillation . J Cell Mol Med . 2020 ; 24 ( 22 ): 13356 – 69 .
Xu F , Fu Y , Sun TY , Jiang Z , Miao Z , Shuai M , et al . The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases . Microbiome . 2020 ; 8 ( 1 ): 145 .
Huang K , Wang Y , Bai Y , Luo Q , Lin X , Yang Q , et al . Gut microbiota and metabolites in atrial fibrillation patients and their changes after catheter ablation . Microbiol Spectr . 2022 ; 10 ( 2 ): e0107721 .
Palmu J , Borschel CS , Ortega-Alonso A , Marko L , Inouye M , Jousilahti P , et al . Gut microbiome and atrial fibrillation-results from a large population-based study . EBioMedicine . 2023 ; 91 : 104583 .
Wang Y , He Y , Li R , Jiang H , Tao D , Zhao K , et al . Gut microbiota in patients with postoperative atrial fibrillation undergoing off-pump coronary bypass graft surgery . J Clin Med . 2023 ; 12 ( 4 ): 1493 .
Tabata T , Yamashita T , Hosomi K , Park J , Hayashi T , Yoshida N , et al . Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs . Heart Vessels . 2021 ; 36 ( 1 ): 105 – 14 .
Fang C , Zuo K , Zhang W , Zhong J , Li J , Xu L , et al . Association between gut microbiota dysbiosis and the CHA2DS2-VASc score in atrial fibrillation patients . Int J Clin Pract . 2022 ; 2022 : 7942605 .
Zuo K , Li J , Fang C , Zhong J , Xu L , Yang X . Alterations of gut viral signals in atrial fibrillation: complex linkage with gut bacteriome . Aging . 2022 ; 14 ( 16 ): 6537 – 53 .
Imhann F , Bonder MJ , Vich Vila A , Fu J , Mujagic Z , Vork L , et al . Proton pump inhibitors affect the gut microbiome . Gut . 2016 ; 65 ( 5 ): 740 – 8 .
Zuo K , Liu X , Wang P , Jiao J , Han C , Liu Z , et al . Metagenomic datamining reveals enrichment of trimethylamine-N-oxide synthesis in gut microbiome in atrial fibrillation patients . BMC Genomics . 2020 ; 21 ( 1 ): 526 .
Pastori D , Carnevale R , Nocella C , Novo M , Santulli M , Cammisotto V , et al . Gut-derived serum lipopolysaccharide is associated with enhanced risk of major adverse cardiovascular events in atrial fibrillation: effect of adherence to Mediterranean diet . J Am Heart Assoc . 2017 ; 6 ( 6 ): e005784 .
Gong D , Zhang L , Zhang Y , Wang F , Zhao Z , Zhou X . Gut microbial metabolite trimethylamine N-oxide is related to thrombus formation in atrial fibrillation patients . Am J Med Sci . 2019 ; 358 ( 6 ): 422 – 8 .
Luciani M , Muller D , Vanetta C , Diteepeng T , von Eckardstein A , Aeschbacher S , et al . Trimethylamine-N-oxide is associated with cardiovascular mortality and vascular brain lesions in patients with atrial fibrillation . Heart . 2023 ; 109 ( 5 ): 396 – 404 .
Papandreou C , Bullo M , Hernandez-Alonso P , Ruiz-Canela M , Li J , Guasch-Ferre M , et al . Choline metabolism and risk of atrial fibrillation and heart failure in the PREDIMED study . Clin Chem . 2021 ; 67 ( 1 ): 288 – 97 .
Jia J , Dou P , Gao M , Kong X , Li C , Liu Z , et al . Assessment of causal direction between gut microbiota-dependent metabolites and cardiometabolic health: a bidirectional mendelian randomization analysis . Diabetes . 2019 ; 68 ( 9 ): 1747 – 55 .
Zhang J , Zuo K , Fang C , Yin X , Liu X , Zhong J , et al . Altered synthesis of genes associated with short-chain fatty acids in the gut of patients with atrial fibrillation . BMC Genomics . 2021 ; 22 ( 1 ): 634 .
Zuo K , Fang C , Liu Z , Fu Y , Liu Y , Liu L , et al . Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling . Int J Biol Sci . 2022 ; 18 ( 10 ): 4219 – 32 .
Fan PC , Chang JC , Lin CN , Lee CC , Chen YT , Chu PH , et al . Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease . J Formos Med Assoc . 2019 ; 118 ( 7 ): 1099 – 106 .
Alonso A , Yu B , Sun YV , Chen LY , Loehr LR , O’Neal WT , et al . Serum metabolomics and incidence of atrial fibrillation (from the atherosclerosis risk in communities study) . Am J Cardiol . 2019 ; 123 ( 12 ): 1955 – 61 .
Zuo K , Fang C , Gao Y , Fu Y , Wang H , Li J , et al . Suppression of the gut microbiota-bile acid-FGF19 axis in patients with atrial fibrillation . Cell Prolif . 2023 ; 26 : e13488 .
Inzaugarat ME , Johnson CD , Holtmann TM , McGeough MD , Trautwein C , Papouchado BG , et al . NLR family pyrin domain-containing 3 inflammasome activation in hepatic stellate cells induces liver fibrosis in mice . Hepatology . 2019 ; 69 ( 2 ): 845 – 59 .
Frissen M , Liao L , Schneider KM , Djudjaj S , Haybaeck J , Wree A , et al . Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury . Hepatology . 2021 ; 73 ( 5 ): 1836 – 54 .
Caceres FT , Gaspari TA , Samuel CS , Pinar AA . Serelaxin inhibits the profibrotic TGF-beta1/IL-1beta axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts . FASEB J . 2019 ; 33 ( 12 ): 14717 – 33 .
Yao C , Veleva T , Jr Scott L , Cao S , Li L , Chen G , et al . Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation . Circulation . 2018 ; 138 ( 20 ): 2227 – 42 .
Luo Y , Zhang Y , Han X , Yuan Y , Zhou Y , Gao Y , et al . Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis . EBioMedicine . 2022 ; 82 : 104087 .
Yang W , Zhang S , Zhu J , Jiang H , Jia D , Ou T , et al . Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis . J Mol Cell Cardiol . 2019 ; 134 : 119 – 30 .
Yue L , Xie J , Nattel S . Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation . Cardiovasc Res . 2011 ; 89 ( 4 ): 744 – 53 .
Shi J , Zhao Y , Wang K , Shi X , Wang Y , Huang H , et al . Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death . Nature . 2015 ; 526 ( 7575 ): 660 – 5 .
Bartolomaeus H , Balogh A , Yakoub M , Homann S , Marko L , Hoges S , et al . Short-chain fatty acid propionate protects from hypertensive cardiovascular damage . Circulation . 2019 ; 139 ( 11 ): 1407 – 21 .
Fang C , Zuo K , Jiao K , Zhu X , Fu Y , Zhong J , et al . PAGln, an atrial fibrillation-linked gut microbial metabolite, acts as a promoter of atrial myocyte injury . Biomolecules . 2022 ; 12 ( 8 ): 1120 .
Nemet I , Saha PP , Gupta N , Zhu W , Romano KA , Skye SM , et al . A cardiovascular disease-linked gut microbial metabolite acts via adrenergic receptors . Cell . 2020 ; 180 ( 5 ): 862 - 77.e22 .
Kilts JD , Gerhardt MA , Richardson MD , Sreeram G , Mackensen GB , Grocott HP , et al . β 2 -adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i) . Circ Res . 2000 ; 87 ( 8 ): 705 – 9 .
Trappe K , Thomas D , Bikou O , Kelemen K , Lugenbiel P , Voss F , et al . Suppression of persistent atrial fibrillation by genetic knockdown of caspase 3: a pre-clinical pilot study . Eur Heart J . 2013 ; 34 ( 2 ): 147 – 57 .
Yue L , Feng J , Gaspo R , Li GR , Wang Z , Nattel S . Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation . Circ Res . 1997 ; 81 ( 4 ): 512 – 25 .
Cha TJ , Ehrlich JR , Chartier D , Qi XY , Xiao L , Nattel S . Kir3-based inward rectifier potassium current: potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias . Circulation . 2006 ; 113 ( 14 ): 1730 – 7 .
Igarashi T , Finet JE , Takeuchi A , Fujino Y , Strom M , Greener ID , et al . Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation . Circulation . 2012 ; 125 ( 2 ): 216 – 25 .
Fang C , Zuo K , Liu Z , Liu Y , Liu L , Wang Y , et al . Disordered gut microbiota promotes atrial fibrillation by aggravated conduction disturbance and unbalanced linoleic acid/SIRT1 signaling . Biochem Pharmacol . 2023 ; 213 : 115599 .
Rainer PP , Primessnig U , Harenkamp S , Doleschal B , Wallner M , Fauler G , et al . Bile acids induce arrhythmias in human atrial myocardium-implications for altered serum bile acid composition in patients with atrial fibrillation . Heart . 2013 ; 99 ( 22 ): 1685 – 92 .
Sheikh Abdul Kadir SH , Miragoli M , Abu-Hayyeh S , Moshkov AV , Xie Q , Keitel V , et al . Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes . PLoS ONE . 2010 ; 5 ( 3 ): e9689 .
Hao H , Cao L , Jiang C , Che Y , Zhang S , Takahashi S , et al . Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasisassociated sepsis . Cell Metab . 2017 ; 25 ( 4 ): 856 - 67.e5 .
Wiegerinck RF , van Veen TAB , Belterman CN , Schumacher CA , Noorman M , de Bakker JMT , et al . Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure . Heart Rhythm . 2008 ; 5 ( 8 ): 1178 – 85 .
Jiang WY , Huo JY , Wang SC , Cheng YD , Lyu YT , Jiang ZX , et al . Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling . J Physiol Biochem . 2022 ; 78 ( 4 ): 855 – 67 .
Zhang L , Xie F , Tang H , Zhang X , Hu J , Zhong X , et al . Gut microbial metabolite TMAO increases peritoneal inflammation and peritonitis risk in peritoneal dialysis patients . Transl Res . 2022 ; 240 : 50 – 63 .
Lazzerini PE , Laghi-Pasini F , Acampa M , Srivastava U , Bertolozzi I , Giabbani B , et al . Systemic inflammation rapidly induces reversible atrial electrical remodeling: the role of interleukin-6-mediated changes in connexin expression . J Am Heart Assoc . 2019 ; 8 ( 16 ): e011006 .
Ryu K , Li L , Khrestian CM , Matsumoto N , Sahadevan J , Ruehr ML , et al . Effects of sterile pericarditis on connexins 40 and 43 in the atria: correlation with abnormal conduction and atrial arrhythmias . Am J Physiol Heart Circ Physiol . 2007 ; 293 ( 2 ): H1231 – 41 .
Sawaya SE , Rajawat YS , Rami TG , Szalai G , Price RL , Sivasubramanian N , et al . Downregulation of connexin 40 and increased prevalence of atrial arrhythmias in transgenic mice with cardiac-restricted overexpression of tumor necrosis factor . Am J Physiol Heart Circ Physiol . 2007 ; 292 ( 3 ): H1561 – 7 .
Chen ML , Zhu XH , Ran L , Lang HD , Yi L , Mi MT . Trimethylamine-N-oxide induces vascular inflammation by activating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway . J Am Heart Assoc . 2017 ; 6 ( 9 ): e006347 .
Hou Y , Scherlag BJ , Lin J , Zhang Y , Lu Z , Truong K , et al . Ganglionated plexi modulate extrinsic cardiac autonomic nerve input: effects on sinus rate, atrioventricular conduction, refractoriness, and inducibility of atrial fibrillation . J Am Coll Cardiol . 2007 ; 50 ( 1 ): 61 – 8 .
Nishida K , Maguy A , Sakabe M , Comtois P , Inoue H , Nattel S . The role of pulmonary veins vs. autonomic ganglia in different experimental substrates of canine atrial fibrillation . Cardiovasc Res . 2011 ; 89 ( 4 ): 825 – 33 .
Yu L , Meng G , Huang B , Zhou X , Stavrakis S , Wang M , et al . A potential relationship between gut microbes and atrial fibrillation: trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation . Int J Cardiol . 2018 ; 255 : 92 – 8 .
Seldin MM , Meng Y , Qi H , Zhu W , Wang Z , Hazen SL , et al . Trimethylamine N-oxide promotes vascular inflammation through signaling of mitogen-activated protein kinase and nuclear factor-kappaB . J Am Heart Assoc . 2016 ; 5 ( 2 ): e002767 .
Wei SG , Yu Y , Zhang ZH , Felder RB . Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat . Hypertension . 2015 ; 65 ( 5 ): 1126 – 33 .
Bravo JA , Forsythe P , Chew MV , Escaravage E , Savignac HM , Dinan TG , et al . Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve . Proc Natl Acad Sci U S A . 2011 ; 108 ( 38 ): 16050 – 5 .
Kimura I , Inoue D , Maeda T , Hara T , Ichimura A , Miyauchi S , et al . Shortchain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) . Proc Natl Acad Sci U S A . 2011 ; 108 ( 19 ): 8030 – 5 .
Goehler LE , Park SM , Opitz N , Lyte M , Gaykema RP . Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior . Brain Behav Immun . 2008 ; 22 ( 3 ): 354 – 66 .
Qiu M , Huang K , Liu Y , Yang Y , Tang H , Liu X , et al . Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis . Mucosal Immunol . 2019 ; 12 ( 4 ): 945 – 57 .
Zhang XY , Chen J , Yi K , Peng L , Xie J , Gou X , et al . Phlorizin ameliorates obesity-associated endotoxemia and insulin resistance in high-fat dietfed mice by targeting the gut microbiota and intestinal barrier integrity . Gut Microbes . 2020 ; 12 ( 1 ): 1 – 18 .
Sun Z , Zhou D , Xie X , Wang S , Wang Z , Zhao W , et al . Cross-talk between macrophages and atrial myocytes in atrial fibrillation . Basic Res Cardiol . 2016 ; 111 ( 6 ): 63 .
Chen WT , Chen YC , Hsieh MH , Huang SY , Kao YH , Chen YA , et al . The uremic toxin indoxyl sulfate increases pulmonary vein and atrial arrhythmogenesis . J Cardiovasc Electrophysiol . 2015 ; 26 ( 2 ): 203 – 10 .
Li D , Shinagawa K , Pang L , Leung TK , Cardin S , Wang Z , et al . Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure . Circulation . 2001 ; 104 ( 21 ): 2608 – 14 .
Qiu H , Ji C , Liu W , Wu Y , Lu Z , Lin Q , et al . Chronic kidney disease increases atrial fibrillation inducibility: involvement of inflammation, atrial fibrosis, and connexins . Front Physiol . 2018 ; 9 : 1726 .
Qiu H , Liu W , Lan T , Pan W , Chen X , Wu H , et al . Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats . Phytomedicine . 2018 ; 51 : 255 – 65 .
Fang J , Kong B , Shuai W , Xiao Z , Dai C , Qin T , et al . Ferroportin-mediated ferroptosis involved in new-onset atrial fibrillation with LPS-induced endotoxemia . Eur J Pharmacol . 2021 ; 913 : 174622 .
Liu D , Yang M , Yao Y , He S , Wang Y , Cao Z , et al . Cardiac fibroblasts promote ferroptosis in atrial fibrillation by secreting exo-miR-23a-3p targeting SLC7A11 . Oxid Med Cell Longev . 2022 ; 2022 : 3961495 .
Li YD , Hong YF , Yusufuaji Y , Tang BP , Zhou XH , Xu GJ , et al . Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation . Mol Med Rep . 2015 ; 12 ( 3 ): 3243 – 8 .
Zhao L , Zhou T , Chen J , Cai W , Shi R , Duan Y , et al . Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling . Drug Deliv . 2022 ; 29 ( 1 ): 2610 – 20 .
Vikram A , Kim YR , Kumar S , Li Q , Kassan M , Jacobs JS , et al . Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1 . Nat Commun . 2016 ; 7 : 12565 .
Huxley RR , Lopez FL , Folsom AR , Agarwal SK , Loehr LR , Soliman EZ , et al . Absolute and attributable risks of atrial fibrillation in relation to optimal and borderline risk factors: the Atherosclerosis Risk in Communities (ARIC) study . Circulation . 2011 ; 123 ( 14 ): 1501 – 8 .
Vinter N , Christesen AMS , Mortensen LS , Urbonaviciene G , Lindholt J , Johnsen SP , et al . Coronary artery calcium score and the long-term risk of atrial fibrillation in patients undergoing non-contrast cardiac computed tomography for suspected coronary artery disease: a Danish registry-based cohort study . Eur Heart J Cardiovasc Imaging . 2018 ; 19 ( 8 ): 926 – 32 .
Mountantonakis SE , Grau-Sepulveda MV , Bhatt DL , Hernandez AF , Peterson ED , Fonarow GC . Presence of atrial fibrillation is independently associated with adverse outcomes in patients hospitalized with heart failure: an analysis of get with the guidelines-heart failure . Circ Heart Fail . 2012 ; 5 ( 2 ): 191 – 201 .
Heidt T , Courties G , Dutta P , Sager HB , Sebas M , Iwamoto Y , et al . Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction . Circ Res . 2014 ; 115 ( 2 ): 284 – 95 .
Chen MC , Chang JP , Liu WH , Yang CH , Chen YL , Tsai TH , et al . Increased inflammatory cell infiltration in the atrial myocardium of patients with atrial fibrillation . Am J Cardiol . 2008 ; 102 ( 7 ): 861 – 5 .
Monnerat G , Alarcon ML , Vasconcellos LR , Hochman-Mendez C , Brasil G , Bassani RA , et al . Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice . Nat Commun . 2016 ; 7 : 13344 .
Kuwahara F , Kai H , Tokuda K , Takeya M , Takeshita A , Egashira K , et al . Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Hypertension . 2004 ; 43 ( 4 ): 739 – 45 .
Lindsey ML , Escobar GP , Mukherjee R , Goshorn DK , Sheats NJ , Bruce JA , et al . Matrix metalloproteinase-7 affects connexin-43 levels, electrical conduction, and survival after myocardial infarction . Circulation . 2006 ; 113 ( 25 ): 2919 – 28 .
Yang Y , Ma L , Wang C , Song M , Li C , Chen M , et al . Matrix metalloproteinase-7 in platelet-activated macrophages accounts for cardiac remodeling in uremic mice . Basic Res Cardiol . 2020 ; 115 ( 3 ): 30 .
Kao YH , Chen YC , Cheng CC , Lee TI , Chen YJ , Chen SA . Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca 2+ -ATPase expressions via the promoter methylation in cardiomyocytes . Crit Care Med . 2010 ; 38 ( 1 ): 217 – 22 .
Cacheux M , Strauss B , Raad N , Ilkan Z , Hu J , Benard L , et al . Cardiomyocyte-specific STIM1 (stromal interaction molecule 1) depletion in the adult heart promotes the development of arrhythmogenic discordant alternans . Circ Arrhythm Electrophysiol . 2019 ; 12 ( 11 ): e007382 .
Nicolas-Avila JA , Lechuga-Vieco AV , Esteban-Martinez L , Sanchez-Diaz M , Diaz-Garcia E , Santiago DJ , et al . A network of macrophages supports mitochondrial homeostasis in the heart . Cell . 2020 ; 183 ( 1 ): 94 - 109.e23 .
Hulsmans M , Clauss S , Xiao L , Aguirre AD , King KR , Hanley A , et al . Macrophages facilitate electrical conduction in the heart . Cell . 2017 ; 169 ( 3 ): 510 - 22.e20 .
De Jesus NM , Wang L , Herren AW , Wang J , Shenasa F , Bers DM , et al . Atherosclerosis exacerbates arrhythmia following myocardial infarction: role of myocardial inflammation . Heart Rhythm . 2015 ; 12 ( 1 ): 169 – 78 .
Le Chatelier E , Nielsen T , Qin J , Prifti E , Hildebrand F , Falony G , et al . Richness of human gut microbiome correlates with metabolic markers . Nature . 2013 ; 500 ( 7464 ): 541 – 6 .
Schulthess J , Pandey S , Capitani M , Rue-Albrecht KC , Arnold I , Franchini F , et al . The short chain fatty acid butyrate imprints an antimicrobial program in macrophages . Immunity . 2019 ; 50 ( 2 ): 432 - 45.e7 .
Chng SH , Kundu P , Dominguez-Brauer C , Teo WL , Kawajiri K , Fujii-Kuriyama Y , et al . Ablating the aryl hydrocarbon receptor (AhR) in CD11c + cells perturbs intestinal epithelium development and intestinal immunity . Sci Rep . 2016 ; 6 : 23820 .
Sun X , Jiao X , Ma Y , Liu Y , Zhang L , He Y , et al . Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome . Biochem Biophys Res Commun . 2016 ; 481 ( 1–2 ): 63 – 70 .
Ma G , Pan B , Chen Y , Guo C , Zhao M , Zheng L , et al . Trimethylamine N-oxide in atherogenesis: impairing endothelial selfrepair capacity and enhancing monocyte adhesion . Biosci Rep . 2017 ; 37 ( 2 ): BSR20160244 .
Yoshida N , Emoto T , Yamashita T , Watanabe H , Hayashi T , Tabata T , et al . Bacteroides vulgatus and Bacteroides dorei reduce gut microbial lipopolysaccharide production and inhibit atherosclerosis . Circulation . 2018 ; 138 ( 22 ): 2486 – 98 .
Hassan A , Din AU , Zhu Y , Zhang K , Li T , Wang Y , et al . Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE -/- mice through modulation of proinflammatory cytokines and oxidative stress . Appl Microbiol Biotechnol . 2020 ; 104 ( 14 ): 6337 – 50 .
Barrio-Lopez MT , Ruiz-Canela M , Ramos P , Tercedor L , Ibañez Criado JL , Ortiz M , et al . PREvention of recurrent arrhythmias with Mediterranean diet (PREDIMAR) study in patients with atrial fibrillation: rationale, design and methods . Am Heart J . 2020 ; 220 : 127 – 36 .
Pastori D , Carnevale R , Menichelli D , Nocella C , Bartimoccia S , Novo M , et al . Is there an interplay between adherence to Mediterranean diet, antioxidant status, and vascular disease in atrial fibrillation patients? . Antioxid Redox Signal . 2016 ; 25 ( 14 ): 751 – 5 .
Liang Z , Dong Z , Guo M , Shen Z , Yin D , Hu S , et al . Trimethylamine N-oxide as a risk marker for ischemic stroke in patients with atrial fibrillation . J Biochem Mol Toxicol . 2019 ; 33 ( 2 ): e22246 .
Zhu W , Wang Z , Tang WHW , Hazen SL . Gut microbe-generated trimethylamine N-oxide from dietary choline is prothrombotic in subjects . Circulation . 2017 ; 135 ( 17 ): 1671 – 3 .
Skye SM , Zhu W , Romano KA , Guo CJ , Wang Z , Jia X , et al . Microbial transplantation with human gut commensals containing cutC is sufficient to transmit enhanced platelet reactivity and thrombosis potential . Circ Res . 2018 ; 123 ( 10 ): 1164 – 76 .
Marques FZ , Nelson E , Chu PY , Horlock D , Fiedler A , Ziemann M , et al . High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice . Circulation . 2017 ; 135 ( 10 ): 964 – 77 .
Chong E , Chang SL , Hsiao YW , Singhal R , Liu SH , Leha T , et al . Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/Akt/eNOS signaling pathway activation . Heart Rhythm . 2015 ; 12 ( 5 ): 1046 – 56 .
Catry E , Bindels LB , Tailleux A , Lestavel S , Neyrinck AM , Goossens JF , et al . Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction . Gut . 2018 ; 67 ( 2 ): 271 – 83 .
Brown GD , Gordon S . Immune recognition. A new receptor for betaglucans . Nature . 2001 ; 413 ( 6851 ): 36 – 7 .
Ryan PM , London LE , Bjorndahl TC , Mandal R , Murphy K , Fitzgerald GF , et al . Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E -/- mice . Microbiome . 2017 ; 5 ( 1 ): 30 .
Zhang Y , Sun D , Zhao X , Luo Y , Yu H , Zhou Y , et al . Bacteroides fragilis prevents aging-related atrial fibrillation in rats via regulatory T cells-mediated regulation of inflammation . Pharmacol Res . 2022 ; 177 : 106141 .
Depommier C , Everard A , Druart C , Plovier H , Van Hul M , Vieira-Silva S , et al . Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study . Nat Med . 2019 ; 25 ( 7 ): 1096 – 103 .
Linz B , Hohl M , Mishima R , Saljic A , Lau DH , Jespersen T , et al . Pharmacological inhibition of sodium-proton-exchanger subtype 3-mediated sodium absorption in the gut reduces atrial fibrillation susceptibility in obese spontaneously hypertensive rats . Int J Cardiol Heart Vasc . 2020 ; 28 : 100534 .
Andraws R , Berger JS , Brown DL . Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials . JAMA . 2005 ; 293 ( 21 ): 2641 – 7 .
Hu X , Li H , Zhao X , Zhou R , Liu H , Sun Y , et al . Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome . Theranostics . 2021 ; 11 ( 12 ): 5778 – 93 .
Li W , Li C , Ren C , Zhou S , Cheng H , Chen Y , et al . Bidirectional effects of oral anticoagulants on gut microbiota in patients with atrial fibrillation . Front Cell Infect Microbiol . 2023 ; 13 : 1038472 .
Orman M , Bodea S , Funk MA , Campo AMD , Bollenbach M , Drennan CL , et al . Structure-guided identification of a small molecule that inhibits anaerobic choline metabolism by human gut bacteria . J Am Chem Soc . 2019 ; 141 ( 1 ): 33 – 7 .
Pathak P , Helsley RN , Brown AL , Buffa JA , Choucair I , Nemet I , et al . Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism . Am J Physiol Heart Circ Physiol . 2020 ; 318 ( 6 ): H1474 – 86 .
Wang Z , Roberts AB , Buffa JA , Levison BS , Zhu W , Org E , et al . Nonlethal inhibition of gut microbial trimethylamine production for the treatment of atherosclerosis . Cell . 2015 ; 163 ( 7 ): 1585 – 95 .
Smits LP , Kootte RS , Levin E , Prodan A , Fuentes S , Zoetendal EG , et al . Effect of vegan fecal microbiota transplantation on carnitine- and choline-derived trimethylamine-N-oxide production and vascular inflammation in patients with metabolic syndrome . J Am Heart Assoc . 2018 ; 7 ( 7 ): e008342 .
Manrique P , Zhu Y , van der Oost J , Herrema H , Nieuwdorp M , de Vos WM , et al . Gut bacteriophage dynamics during fecal microbial transplantation in subjects with metabolic syndrome . Gut Microbes . 2021 ; 13 ( 1 ): 1 – 15 .
Martin-Cabezas R , Seelam N , Petit C , Agossa K , Gaertner S , Tenenbaum H , et al . Association between periodontitis and arterial hypertension: a systematic review and meta-analysis . Am Heart J . 2016 ; 180 : 98 – 112 .
Schaefer AS , Bochenek G , Jochens A , Ellinghaus D , Dommisch H , Güzeldemir-Akçakanat E , et al . Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis . Circ Cardiovasc Genet . 2015 ; 8 ( 1 ): 159 – 67 .
Chen DY , Lin CH , Chen YM , Chen HH . Risk of atrial fibrillation or flutter associated with periodontitis: a nationwide, population-based, cohort study . PLoS One . 2016 ; 11 ( 10 ): e0165601 .
Yu G , Yu Y , Li YN , Shu R . Effect of periodontitis on susceptibility to atrial fibrillation in an animal model . J Electrocardiol . 2010 ; 43 ( 4 ): 359 – 66 .
Chang Y , Woo HG , Park J , Lee JS , Song TJ . Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: a nationwide population-based cohort study . Eur J Prev Cardiol . 2020 ; 27 ( 17 ): 1835 – 45 .
0
浏览量
1
Downloads
0
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies