Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

Lu Tang; Zhong-Pei Huang; Heng Mei; Yu Hu

doi:10.1186/s40779-023-00486-4

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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

REVIEW | Updated：2025-12-13

- Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
- Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
- “嵌合抗原受体（CAR）-T细胞治疗的进展显著改善了复发或难治性血液系统恶性肿瘤患者的临床结果。然而，由于临床效益仅适用于一小部分患者，因此进展仍然受到阻碍。在这篇综述中，我们讨论了CAR-T免疫疗法在临床实践中失败的原因，以及自单细胞测序技术里程碑以来该领域所取得的进展。xx专家建立了xx系统/探索了xx课题/验证了xx猜想，为解决xx问题提供了解决方案/为xx研究开辟了新的方向/为xx系统的建设奠定了基础。”
- MMR 2024年11卷第5期页码：717-746
- Affiliations：
  
  1.Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  2.Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan 430022, China
  3.Key Laboratory of Biological Targeted Therapy, the Ministry of Education, Wuhan 430022, China
  4.Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
- Author bio：
  
  *hmei@hust.edu.cn;
  dr_huyu@126.com
- Funds：
  
  the National Key Research and Development Program of China(2022YFC2502700);the National Natural Science Foundation of China(81873434;82100190)
- DOI：10.1186/s40779-023-00486-4
  中图分类号：
- 纸质出版：2024-10
- Accepted：
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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer[J]. MMR, 2024,11(5):717-746.

Cite this article as: Tang L, Huang ZP, Mei H, Hu Y. Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer. Mil Med Res. 2023;10(1):52.
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer[J]. MMR, 2024,11(5):717-746. DOI： 10.1186/s40779-023-00486-4.

Cite this article as: Tang L, Huang ZP, Mei H, Hu Y. Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer. Mil Med Res. 2023;10(1):52. DOI： 10.1186/s40779-023-00486-4.

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Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer

DOI：10.1186/s40779-023-00486-4