Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism

Peng-Zi Zhang; Ying-Huan Shi; Yu-Xin Guo; Ya-Yuan Li; Hong-Li Yin; Tian-Yu Wu; Ye Zhu; Jia-Xuan Jiang; Yan Bi

doi:10.1186/s40779-025-00609-z

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Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism

RESEARCH | Updated：2026-01-27

- Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
- Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism
- “在代谢紊乱领域，研究人员取得了重大进展。专家们已经建立了社会时差诱导脂肪肝的因果机制，为治疗代谢功能障碍相关的脂肪变性肝病提供了新的方向。”
- Military Medical Research 2025年12卷第11期页码：1703-1721
- Affiliations：
  
  1.Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
  2.Branch of National Clinical Research Centre for Metabolic Diseases, Nanjing 210008, China
  3.National Key Laboratory for Novel Software Technology and the National Institute of Healthcare Data Science, Nanjing University, Nanjing 210008, China
- Author bio：
  
  * Yan Bi biyan@nju.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82030026;81900787;81770819;82300877;82450002);the Key Project supported by Medical Science and technology development Foundation, Nanjing Department of Health(YKK24104);the Medical Research Program of Jiangsu Provincial Health Committe(M2024050);the China Postdoctoral Science Foundation(2023M731628)
- DOI：10.1186/s40779-025-00609-z
  中图分类号：
- 收稿：2024-08-26，
  
  录用：2025-04-25，
  
  网络首发：2025-06-03，
  
  纸质出版：2025-11
- Accepted：
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Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, 等. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025,12(11):1703-1721.

Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, et al. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025, 12(11): 1703-1721.
Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, 等. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025,12(11):1703-1721. DOI： 10.1186/s40779-025-00609-z.

Peng-Zi Zhang, Ying-Huan Shi, Yu-Xin Guo, et al. Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism[J]. Military Medical Research, 2025, 12(11): 1703-1721. DOI： 10.1186/s40779-025-00609-z.

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Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism

Social jetlag elicits fatty liver via perturbed circulating prolactin rhythm-mediated circadian remodeling of hepatic lipid metabolism

DOI：10.1186/s40779-025-00609-z