Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

Yogesh Godiyal; Drishti Maheshwari; Hiroaki Taniguchi; Shweta S. Zinzuwadia; Yanelys Morera-Díaz; Devesh Tewari; Anupam Bishayee

doi:10.1186/s40779-024-00586-9

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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

REVIEW | Updated：2025-12-13

- Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy
- Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy
- “在与癌症的斗争中，一篇综述论文强调了天然化合物靶向PD-1/PD-L1途径的潜力，为癌症研究提供了新的方向。”
- Military Medical Research 2025年12卷第10期页码：1567-1616
- Affiliations：
  
  1.Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India
  2.Department of Experimental Embryology, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec,05-552 Magdalenka, Poland
  3.African Genome Center, Mohammed VI Polytechnic University, Hay Moulay Rachid, 43150 Ben Guerir, Morocco
  4.Department of Pharmacology, College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
  5.Clinical Investigation and Biomedical Research Directions, Center for Genetic Engineering and Biotechnology, 11600 Havana, Cuba
- Author bio：
  
  * Devesh Tewari devesh.tewari@dpsru.edu.in; dtewari3@gmail.com
  Anupam Bishayee abishayee@lecom.edu; abishayee@gmail.com
- Funds：
- DOI：10.1186/s40779-024-00586-9
  中图分类号：
- 收稿：2024-07-08，
  
  录用：2024-11-29，
  
  网络首发：2024-12-18，
  
  纸质出版：2025-10
- Accepted：
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Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, 等. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025,12(10):1567-1616.

Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, et al. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025, 12(10): 1567-1616.
Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, 等. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025,12(10):1567-1616. DOI： 10.1186/s40779-024-00586-9.

Yogesh Godiyal, Drishti Maheshwari, Hiroaki Taniguchi, et al. Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy[J]. Military Medical Research, 2025, 12(10): 1567-1616. DOI： 10.1186/s40779-024-00586-9.

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Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

Role of PD-1/PD-L1 signaling axis in oncogenesis and its targeting by bioactive natural compounds for cancer immunotherapy

DOI：10.1186/s40779-024-00586-9