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Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis
RESEARCH | Updated：2026-03-06

    • Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis

    • Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis

    • “研究人员在炎症性疾病治疗领域取得了重大进展。通过探索抗四联蛋白抗体表位的治疗潜力，他们开发了P2-1，一种水溶性衍生物。这种靶向治疗显著提高了脓毒症模型的存活率，减少了炎症，并减轻了RA模型的关节炎严重程度和疼痛。该研究引入了一种新的药物发现策略，将有害抗体的见解转化为HMGB1-pCTS-L轴的靶向治疗。”
    • Military Medical Research   2025年12卷

    • DOI：10.1186/s40779-026-00686-8    

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    • 收稿：2025-10-03，

      录用：2026-01-30，

      网络首发：2026-02-17，

      纸质出版：2025

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  • Wei-Qiang Chen, Li Lou, Xiao-Ling Qiang, 等. Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis[J/OL]. Military Medical Research, 2025,12. DOI： 10.1186/s40779-026-00686-8.

    Wei-Qiang Chen, Li Lou, Xiao-Ling Qiang, et al. Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis[J/OL]. Military Medical Research, 2025, 12. DOI： 10.1186/s40779-026-00686-8.

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