CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation

Yu Liu; Jing-Song Xu; Li Cao; Shuang Yang; Tian-Ming Li; Hai-Qian Huang; Jun-Heng Zhang; Xue Zhao; Qian Liu; Shun Li; Min Li; Hua Wang

doi:10.1186/s40779-025-00632-0

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CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation

RESEARCH | Updated：2026-01-27

- CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation
- CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation
- “在器官移植领域，开发了一种基于CRISPR的新型检测平台，建立了一锅RPA-CRISPR反应系统，并对其进行了优化，用于BKV和JCV检测。该平台可以同时快速检测BKV和JCV，灵敏度高，提供绝对定量，适用于病毒载量检测，有利于器官移植受者的个性化和精确治疗。”
- Military Medical Research 2025年12卷第12期页码：1904-1919
- Affiliations：
  
  1.Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  2.Department of Pathology, the Fifth People’s Hospital of Shanghai, Fudan University, Shanghai 200240, China
  3.Central Laboratory, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
  4.Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
- Author bio：
  
  * Qian Liu qq2005011@163.com
  Shun Li lishun86@126.com
  Min Li rjlimin@shsmu.edu.cn
  Hua Wang renjijywh@shsmu.edu.cn
- Funds：
  
  the National Key Research and Development Program(2023YFC2306200);the National Natural Science Foundation of China(82472374);the Cross-Research Fund of Biomedical Engineering of Shang-hai Jiaotong University(YG2024LC02);the Clinical Excellence project of Shanghai Key Laboratory of Nucleic Acid Chemistry and Nanomedicine(2024ZY008)
- DOI：10.1186/s40779-025-00632-0
  中图分类号：
- 收稿：2024-11-08，
  
  录用：2025-07-19，
  
  网络首发：2025-08-04，
  
  纸质出版：2025-12
- Accepted：
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Yu Liu, Jing-Song Xu, Li Cao, 等. CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation[J]. Military Medical Research, 2025,12(12):1904-1919.

Yu Liu, Jing-Song Xu, Li Cao, et al. CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation[J]. Military Medical Research, 2025, 12(12): 1904-1919.
Yu Liu, Jing-Song Xu, Li Cao, 等. CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation[J]. Military Medical Research, 2025,12(12):1904-1919. DOI： 10.1186/s40779-025-00632-0.

Yu Liu, Jing-Song Xu, Li Cao, et al. CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation[J]. Military Medical Research, 2025, 12(12): 1904-1919. DOI： 10.1186/s40779-025-00632-0.

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CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation

CRISPR-based assays for the detection of BK virus and JC virus infections post-kidney transplantation

DOI：10.1186/s40779-025-00632-0