Issue Ebook
cover story
Latest Issue
Volume ， Issue 1 ， 1988
- Abstract：<正> Here presents a brief summation of studies on the home-made drughydroxypiperaquine,which has been shown to be an effective malarial suppressant.The chemistry,antimalarial activity,clinical efficacy in malarial chemotherapy aswell as the principal toxicity data of this drug are summarized in this paper.0|16|0Updated：2026-03-12
- Abstract：<正> The repairing capacities of bone matrix gelatin（BMG）,decalcified bonematrix（DBM）and deep frozen bone（DFB）were tested in experimental defects onskulls of rats.The healing of defects were judged by roentgenographic,histological and atomic absorption spectrophotometric methods.The healing ofdefects was most effective with BMG（P<0.01）,and DMB came next while thecapability of bone induction was very weak in DFB.In the BMG and DBMgroups,skull defects were completely healed in 12 weeks after the operation,but inthe DFB group healing was incomplete.The control group failed to healspontaneously.The results suggest that during the process of resorption of BMGand DBM,bone morphogenetic protein（BMP）was released by diffusion,whichinduced mesenchymal cells originating from the dura mater to differentiate intochondrocytes and osteobIasts,resulting in formation of new bone.The inducedosteogenesis is considered to be a complex process regulated not only by BMP butalso by various systemic and local growth factors.0|7|1Updated：2026-03-12
- Abstract：<正> The influence of shock in varied degreeson pial-microcirculation in rats and thedynamic change of pial-microcirculation inhypotension were observed.It was shown thatsevere disturbance occurred inpial-microcirculation when blood pressure was0|0|0Updated：2026-03-12
- Abstract：<正> The effects of added airflow resistance（0.3-3 kPa·L.（-1）·s）on therespiratory flow rate and mask cavity pressure as well as the subject’s perceptionwere investigated in 114 pilots under light physical activities(250kg·m·min-).A correlation and stepwise regression analysis was made to reveal the objectivephysiological indexes which could reflect the effects of the added resistance, and aprobit analysis was made to confirm the permissible levels for added resistance.The results suggest that both mask cavity pressure swing（P） and extra respiratorywork per unit ventilation(W.L-1)could be used as the objective physiological,,indexes for respiratory discomfort,and the former may be more applicable.If Pdoes not exceed 0.60kPa or if W L-1does not exceed 0.047 kg·m L-1,90％ ofthe subjects will feel no respiratory discomfort;if P does not exceed 0.77kPa orW·L-1not exceed 0.061 kg·m·L-1,90％ may only feel less than mediumrespiratory discomfort.The problem concerning the revision of the currentstandards of respiratory resistance of aircraft oxygen equipment is discussed inthis paper.0|8|0Updated：2026-03-12
- Abstract：<正> It has been known that the antimalarial drugs of aminoquinolinesincluding 8-aminoquinolines may cause inhibition of heart conduction or evenAdams-Stokes syndrome,but their morphologic bases were obscure.The purposeof the present study is to define the histological and ultrastructural features ofprimaquine in mammals including dogs,monkeys and rats in the subacute toxicexperiments with the stress on the morphological alteration of the heart.In most（11/16）of the intoxicated dogs,granular degeneration,eosinophilic degeneration,coagulation necrosis,vacuolar degeneration and colliquative myocytolysis werefound in the myocardium and conduction systems.Under electron microscopicstudy,the myocardial cells of intoxicated dogs showed swelling of mitochondria,dilatation of transverse tubules and sarcoplasmic reticulum,fusion or dissolutionof myofibrils,deformity of nuclei,clumping of chromatin,and eventually cellnecrosis.The severities of lesions were dose dependent.These lesions weresupposed to be the morphologic evidence of the toxic symptoms and signs caused byprimaquine.A few rats also revealed myocardial eosinophilic degeneration.Noimportant cardiac lesions were found in the monkeys,but the pathologic changesin the liver were obvious.Different species of laboratory animals showed differentorgan sensitivities to primaquine,but the heart lesions should be considered as animportant toxic effect of primaquine.0|1|0Updated：2026-03-12
- Abstract：<正> Xeroderma pigmentosum（XP）is an inbornautosomal recessive inheritance disease withDNA repair deficiency.XP has become anideal experimental model to study human DNArepair system and the mechanism of cancer.XP 4SH cell line in this report was obtainedfrom the skin tissue of XP patients.After cellculture,XP 4SH cell line showed thecharacteristics of form and growth of fibroblast0|3|0Updated：2026-03-12
- Abstract：<正> Dynorphin A is an endogenous opiatepeptide first extracted from the pig pituitary byGoldstein in 1979.The purpose of this studywas to observe the changes in dynorphin A1-13content in the pituitary and brain areas ofburned rats.Using PIA,the following resultswere obtained:（1）Immediately after burning,0|0|0Updated：2026-03-12
- Abstract：<正> Fluorescent histochemical observation and estimation of the content ofcatecholamine（CA）in cerebral cortex of twenty rats with unilateral occlusion ofmiddle cerebral artery were performed in this present study.Three d after localcerebral infarction,the CA granules which were of different fluorescent featurefrom those of normal cortex were seen in the marginal area of infarct. The contentof norepinephrine in bilateral cortexes was significantly reduced, but that ofdopamine was unchanged.0|0|0Updated：2026-03-12
- Abstract：<正> Thirteen goats with chronic lung lymph fistula were inflicted withsmoke inhalation injury.Thromboxane A2（TXA2 in terms of thromboxane B2 orTXB2）and prostacyclin(PGl2 in terms of 6-keto-prostaglandin F1xor6-keto-PGF1x)in plasma,lung lymph and lung tissue were measured withradioimmunoassay（RIA）.Extravascular lung water（EVLW）,lung lymph flow（QL）,the ratio of protein contents between lung lymph and plasma（LIP）,hemodynamic parameters,blood gases,platelet and leukocyte counts were alsodetermined.EVLW,QL and L/P increased significantly at the 1st hour,reachedtheir peak values at the 2nd hour,then declined gradually and remained at a levelover the baseline at the 6th hour after injury.TXA2 and PGl2 also increasedmarkedly and the.changes of TXA2 and TXA2/PGI2 ratio were in parallel withthose of EVLW,QL and LIP both in degree and in length of time.It is possiblethat the increased TXA2 and TXA2/PGI2 ratio might participate in the formationof permeability pulmonary edema through direct injury and for chemical mediatorsreleased by platelet and leukocyte aggregations promoted by TXA2.In addition,TXA2 might also play a role in the early elevation of pulmonary arterial pressure.0|8|1Updated：2026-03-12
- Abstract：<正> Spleen cells of BALB/C mice immunizedwith medical urokinase were fused with FO andNS-1 myeloma cells three times,and sixhybridoma cell lines（I-UB5,I-UD2,3-UA2,3-UD12,3-UG2 and 3-UH7）secretingmonoclonal antibodies against urokinase wereobtained after screening.Of them,I-UB5 and0|2|0Updated：2026-03-12
- Abstract：<正> From May,1961 to December,1985,25patients with myasthenia gravis（MG）weretreated by radiation with deep X-ray and 109patients with （60）Co mainly on the thymus,followed up from 2 months to 24 years.890|0|0Updated：2026-03-12
- Abstract：<正> To elucidate the adaptation of respiratory sensation to added breathingresistance,changes of ventilation,breathing pattern,and perceived magnitude（PM）of respiratory sensation were observed in 11 healthy young male subjectswith inspiratory resistive loadings for 40,30,and 20 rain at rest and in light (200kg.m.rain-1),and moderate(600 kg.m.rain-1)physical activities respectively.Themain results are as follows:（1）With inspiratory load lasting 30 and 20 rain inlight and moderate physical activities respeetively,VImax,VI,f,MV,Plmax.andWI increased,and TI and VTI decreased;but PETco2 decreased apparently only atmoderate work rate due to the accompanying hyperventilation.（2）Adaptation ofrespiratory sensation occurs,if the intensity of the added inspiratory load does notexceed the“moderate”degree and for the physical load is lower than the“light”degree.0|2|0Updated：2026-03-12
- Abstract：<正> We studied the changes of pulmonary vascular permeability andlipoperoxides in scalded rats with full-thickness damage 40％ of bow surface. Theresults showed that both pulmonary vascular permeability and lipoperoxides inserum and lung homogenate increased significantly 2 h after scalding.Subsequently,interstitial and alveolar edema developed.Pulmonary vascularpermeability was strongly correlated with lung lipoperoxides（r=0.992）.SerumCH50was decreased to 56.8％ 1 h after scalding,and at the same time,neutrophilcount increased in pulmonary interstitium and vasculature.The increase inpulmonary vascular permeability and lipoperoxides could be prevented with largedose of vitamin E and neutropenia.The results indicate that the lipoperoxidationof pulmonary vascular endothelial cells secondary to complement activation andpulmonary leukostasis is the major cause of increase in pulmonary vascularpermeability after scalding.0|1|0Updated：2026-03-12
- Abstract：<正> In this study,the plasma and erythrocyte（RBC）lipoperoxidation rates,the contents of antioxidant vitamin E（VE）and the activities of antioxidationenzyme SeGSHPx of plasma and RBC in the patients with burn were determinedon the 1st,3rd,5th,10th and 15th days after burn.The results showed that ascompared with healthy subjects,the contents of Iipoperoxide were increased,and thelevels of VE and the activities of SeGSHPx were decreased significantly.Thechanges became more significant with the time elapsing,and the most significantchanges were on the 10tb days postburn.In the meantime the percentages of RBCspontaneous hemolysis and the activities of SeGSHPx were increased,and thecontents of VE in RBC were decreased markedly.The regularity of the changes inthe lipoperoxidation rates of plasma and RBC was in accordance with that in thecontents of VE in them.The degrees of the changes in the LPO and VE contentsand the SeGSHPx activities in plasma were in relation to the extents of burn.Onthe 53th,65th and 85th days during recovery postburn,the changes were stillsignificant compared to the healthy subjects,although they had a tendency torestore.0|3|0Updated：2026-03-12
- Abstract：<正> The effects of zymosan-activated plasma（ZAP）on lung fluid exchangeand on superoxide anion production by granulocytes were studied in 8 consciousgoats with chronic lung lymph fistula,It was found that after ZAP infusion, thecirculating granulocytes were activated and the release of superoxide anions wasmarkedly enhanced. There was an increase in lung lymph flow and proteinconcentration.It suggests that the superoxide anion released by the stimulatedgranulocytes can play a role in inducing lung injury by the activated complement.0|1|0Updated：2026-03-12
- Abstract：<正> Experimental resptratory distress syndrome（RDS）produced by IV oleicacid injection m 61 rabbits was studied A method of retrograde perfusion wasdeveloped by us Microemboli and leukocytes were obtained directly from thepulmonary m（?）rculation by this method,and at the same time cardiacimpedance parameters were determined In this animal model,it was found that agreat number of microemboli and leukocytes were deposited in the pulmonarymicroctrculation,as compared with the normal control group,The microemboliwere l×10 l in normal contrast,but 19.7×106/L in the oleic acid experimentalgroup（P,0.01）,The leukocytes were 430.7×106/L and 2.390×106/L,respectively（P<O.01）It was also found that basic impedance Zo increased,stroke-volume（SV）,cardiac output（CO）and cardiac index（CI）all decreased（P<0.01）.Thedeposit of mwroemboh and leukocytes may be related to the increased permeabilityof the pulmonary blood vessels and the decreased pulmonary blood flow.This typeof lung edema was not caused by the increased blood flow0|2|0Updated：2026-03-12
- Abstract：<正> A new technigue to use forearm free flap for reconstructingcarcinoma-or benign tumor-related defects of the tongue is reported.Vasoneuralpedicles were anastomosed to their counterparts in the submandibular areathrough the floor of the mouth.Of the twenty-one cases that received treatment,only 2 failures were observed.The technique achieved success in the rest 19,αhigh success rate of tissue transplantation in intraoral use.0|0|0Updated：2026-03-12
- Abstract：<正> The secretory component（SC）whichlocalized in the epithelial ceils of bile ductsand interlobular bile ductules of normal humanliver was confirmed by the indirectimmunofluorescence technique usingFITC-labelled rabbit IgG and rabbit anti-SC0|1|0Updated：2026-03-12
- Abstract：<正> This paper describes the experimentalresearch on effects of plaster-of-Parisparticulate implants in mandibular bone cavity.Eighteen animals used in this experiment weredivided into groups A and B.Group A0|1|0Updated：2026-03-12
- Abstract：<正> Cytological characteristics of a case ofadult T-cell leukemia were studied by detectionof morphologic,cytochemical andimmunological methods.The leukemic cells0|0|0Updated：2026-03-12
- Abstract：<正> Twenty male wistar rats were divided intonaloxone group and control group,and theirbacks were dipped into boiling water,whichresulted in deep Ⅱor Ⅲ degree burn of about20% of BSA.Naloxone or normal saline wereinjected into lateral ventricle and0|0|0Updated：2026-03-12
- Abstract：<正> Anisodamine（654-2）was administered to treat the acute experimentalserum sickness tn rabbits induced by a single bolus intravenous injection of bovineserum albumin in order to observe the immunomodulant effects of 654-2 on acuteserum sickness The resalts indicate that the administration of 654-2 can lead to adecrease of the serum levels of specific IgG antibody and immune complex,aninhibition of cathespin D activity,slight changes of the serum level of complementand improvement of renal injuries,0|3|0Updated：2026-03-12
- Abstract：<正> The present study has been carried out in 10 dogs,in which fibronectinin wound fluid and plasma was measured with single radial immunodiffusion.Fibronectin in wound fluid rose from 24 h to 7 d after fracture.The meanincrease of fibronectin level was 0.79（P>0.01）,1.76（P<0.01）,3.07（P<0.001）and4.82（P<0.01）fold at 48,72 h,5 and 7 d,respectively,as comparison with 24 hafter fracture.Plasma fibronectin levels were markedly reduced 6 to 72 h afterfracture.The mean decline was 19.2％（P<0.01）,18.0％（P<0.01）,28.0％（P<0.01）and 9.2％（P<0.05）at 6,24,48 and 72 h,respectively.To our knowledge, therehas been no report on the regularity of the changes of fibronectin in wound fluidbefore,and a close correlation（r=0.9986;P<0.001） between the increase offibronectin levels and wound healing.A hypothesis,based on our study andcurrent literature,is presented that the increase of fibronectin in extracellularenvironment and the loss on cellular surface initiate,control and regulate themain biologic process of wound healing.0|2|2Updated：2026-03-12
- Abstract：<正> An efficient BASIC program was established on Apple-Ⅱmicrocomputer with the CHESTAC-35F pulmonary function testing system tocalculate the time-constant histogram from the spirogram.By a set of analogousstudies,we confirmed that the recovered time-constant histogram was within onecompartment of the assumed one and that the root of mean square values of theresiduals between the experimental and model volume-time curves was 0.02.Infour healthy adult subjects,the mean value of time-constant histograms（TCx）hadthe variation coefficient 6.6％.The results show that our method is reliable andreproducible,and it can be used for clinical investigation.0|0|0Updated：2026-03-12
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
0