Latest Issue

    2025 Year 12 Volume 6 Issue

      RESEARCH

    • Reporting on the latest research in the field of hemorrhagic stroke, a study from the Global Burden of Disease Study (GBD) 2021 reveals that the incidence of subarachnoid hemorrhage (SAH) has increased by 37.09% from 1990 to 2021, yet age-standardized rates have shown a decline. The burden of SAH, influenced by gender, age, and region, is particularly significant in areas with middle and low-middle socio-demographic index (SDI) levels, with high systolic blood pressure identified as a key risk factor. This research provides a foundation for developing targeted interventions to reduce the global impact of SAH.
      2025, 12(6): 822-835. DOI: 10.1186/s40779-024-00551-6
      Epidemiological trends of subarachnoid hemorrhage at global, regional, and national level: a trend analysis study from 1990 to 2021
        
      33
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222274 false
      Updated:2025-12-13
    • In the field of cardiovascular surgery, a phase 3 trial of tetracosactide (TCS10) targeting melanocortin receptors (MCRs) demonstrated significant improvement in 30-day mortality and reduced blood transfusion episodes. Expert sensitivity analysis using the Naïve Bayes classifier and density-based sensitivity index provides a new direction for improving surgical rescue outcomes in critically ill patients.
      2025, 12(6): 836-851. DOI: 10.1186/s40779-024-00555-2
      Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
        
      26
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222272 false
      Updated:2025-12-13
    • In a study on chronic Gulf War Illness, FDA-approved CBD Epidiolex® was found to alleviate cognitive and mood impairments, as well as hyperalgesia, in rats with chronic GWI. The improvements were attributed to CBD's ability to suppress signaling pathways that perpetuate chronic neuroinflammation.
      2025, 12(6): 852-874. DOI: 10.1186/s40779-024-00563-2
      FDA-approved cannabidiol [Epidiolex<sup>®</sup>] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
        
      25
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222275 false
      Updated:2025-12-13
    • Reporting on the latest advancements in the field of acute aortic dissection (AAD) care, a study conducted by the National Chest Pain Center Program (NCPCP) in China has shown that accreditation of chest pain centers (CPC) significantly improves patient outcomes. The research, which analyzed data from 40,848 AAD patients across 1671 hospitals from 2016 to 2022, revealed that post-accreditation, there was a substantial decrease in in-hospital mortality and misdiagnosis rates, and an increase in Stanford type A AAD surgery rates. Expert analysis indicates that CPC accreditation is associated with reduced risks of in-hospital mortality and misdiagnosis, and an increase in the proportion of patients undergoing surgery, particularly in Western regions and non-provincial cities. This study lays a foundation for enhancing the management and in-hospital outcomes for AAD patients.
      2025, 12(6): 875-886. DOI: 10.1186/s40779-024-00565-0
      Effectiveness of chest pain center accreditation on the hospital outcome of acute aortic dissection: a nationwide study in China
        
      24
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222276 false
      Updated:2025-12-13
    • In a groundbreaking study, researchers investigated the short-term prevalence of frailty among burn survivors and compared it with the general population. The findings suggest a higher incidence of post-discharge frailty among burn survivors, highlighting the need for early identification and a multidisciplinary approach to address this issue.
      2025, 12(6): 887-902. DOI: 10.1186/s40779-024-00568-x
      Frailty as a sequela of burn injury: a post hoc analysis of the "RE-ENERGIZE" multicenter randomized-controlled trial and the National Health Interview Survey
        
      18
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222431 false
      Updated:2025-12-13

      REVIEW

    • Advances in the mechanism of small nucleolar RNA and its role in DNA damage response AI Introduction

      In the field of genomic stability maintenance, experts have systematically reviewed the research progress of small nucleolar RNAs (snoRNAs) in DNA damage response (DDR). This study explores the biosynthesis, classification, and regulatory mechanisms of snoRNAs, as well as their role in DDR and significance in disease diagnosis and treatment, laying a foundation for the construction of the snoRNA system.
      2025, 12(6): 903-937. DOI: 10.1186/s40779-024-00553-4
      Advances in the mechanism of small nucleolar RNA and its role in DNA damage response
        
      26
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222445 false
      Updated:2025-12-13
    • Targeting mitochondrial quality control: new therapeutic strategies for major diseases AI Introduction

      In the field of mitochondrial quality control, this review systematically summarizes its three fundamental characteristics and explores innovative approaches for treating major diseases. It offers a novel perspective on understanding the mechanisms underlying major diseases and provides theoretical support and practical guidance for clinical implementation of innovative therapeutic strategies.
      2025, 12(6): 938-971. DOI: 10.1186/s40779-024-00556-1
      Targeting mitochondrial quality control: new therapeutic strategies for major diseases
        
      46
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222448 false
      Updated:2025-12-13

      LETTER TO THE EDITOR

    • Gut microbiota helps identify clinical subtypes of Parkinson’s disease AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, they have provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(6): 972-974. DOI: 10.1186/s40779-024-00545-4
      Gut microbiota helps identify clinical subtypes of Parkinson’s disease
        
      30
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222449 false
      Updated:2025-12-13
    • The Frank-Starling mechanism is not enough: blood volume expansion prominently decreases pulmonary O2 uptake AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(6): 975-977. DOI: 10.1186/s40779-024-00546-3
      The Frank-Starling mechanism is not enough: blood volume expansion prominently decreases pulmonary O<sub>2</sub> uptake
        
      15
      |
      1
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222451 false
      Updated:2025-12-13
    • In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(6): 978-980. DOI: 10.1186/s40779-024-00552-5
        
      18
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222530 false
      Updated:2025-12-13
    • A prediction model for moderate to severe acute kidney injury in people with heart failure AI Introduction

      In the field of xxx, expert xx has made significant progress. They established the xx system/explored the xx topic/verified the xx conjecture, offering solutions to tackle xx problems and paving the way for future research in xx.
      2025, 12(6): 981-984. DOI: 10.1186/s40779-024-00558-z
      A prediction model for moderate to severe acute kidney injury in people with heart failure
        
      31
      |
      0
      |
      0
      <HTML>
      <网络PDF><Meta-XML>
      <Citation> <Bulk Citation> 120222547 false
      Updated:2025-12-13
    0