Latest Issue

    2025 Year 12 Volume 5 Issue

      PERSPECTIVE

    • Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering AI Introduction

      Reporting on the latest research advancements, the study delves into the mechanisms behind gastrointestinal disorders in Gulf War Illness, revealing that neuroinflammation alters gut motility and drives symptoms. Expert insights suggest in vitro bioengineering models could be pivotal in understanding and treating GWI-related gastrointestinal pathology.
      2025, 12(5): 641-658. DOI: 10.1186/s40779-024-00547-2
      Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering
        
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      RESEARCH

    • PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis AI Introduction

      In a groundbreaking study, researchers unveil the pivotal role of PANX1-mediated ATP release in maintaining hepatic glucolipid homeostasis, shedding light on FAM3A's suppressive effects on hepatic gluconeogenesis and lipogenesis.
      2025, 12(5): 659-685. DOI: 10.1186/s40779-024-00543-6
      PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
        
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    • In the field of Parkinson's disease treatment, researchers have made significant progress. They found that transforming growth factor-β1 (TGF-β1) secreted from hypoxia-preconditioned olfactory mucosa-mesenchymal stem cells (hOM-MSCs) plays a critical role in modulating mitochondrial function recovery in dopaminergic neurons, providing a new direction for PD research.
      2025, 12(5): 686-715. DOI: 10.1186/s40779-024-00550-7
      TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients
        
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    • In a recent study, researchers at VA Boston, MA, investigated the relationship between sleep quality and brain volume changes in veterans, particularly those with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). The study found that poor sleep quality is significantly associated with decreased cortical thickness in veterans with mTBI, either alone or comorbid with PTSD, primarily within frontal regions. This finding may have important implications for the treatment of veterans who have sustained mTBI.
      2025, 12(5): 716-726. DOI: 10.1186/s40779-024-00557-0
      Poor sleep and decreased cortical thickness in veterans with mild traumatic brain injury and post-traumatic stress disorder
        
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    • Reporting on the latest research, experts have established the National Disease Surveillance Points system, which explores age-specific temporal trends in mortality for cervical and breast cancers in urban and rural areas of China from 2009 to 2021. This study provides solutions to address rural-urban disparities in cancer control programs and promotes health equity.
      2025, 12(5): 727-740. DOI: 10.1186/s40779-024-00561-4
      National age-specific mortality trends for cervical and breast cancers in urban-rural areas of China from 2009 to 2021: a population-based analysis
        
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      REVIEW

    • Digital in-line holographic microscopy for label-free identification and tracking of biological cells AI Introduction

      Digital in-line holographic microscopy (DIHM), a non-invasive, real-time, label-free technique, captures 3D positional, orientational, and morphological information from living biological cells. This review outlines the fundamental principles and comprehensive digital image processing procedures employed in DIHM-based cell tracking methods. Leveraging artificial intelligence has significantly enhanced both the speed and accuracy of digital image processing for cell tracking and identification, which provides solutions to solve problems in label-free identification and digital tracking of various motile biological cells.
      2025, 12(5): 741-763. DOI: 10.1186/s40779-024-00541-8
      Digital in-line holographic microscopy for label-free identification and tracking of biological cells
        
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    • Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family AI Introduction

      Reporting on the latest research, the paper delves into the role of fibroblast growth factor (FGF) signaling in orthopedic diseases, highlighting its regulation of cartilage and bone health. Expert research has identified potential FGF signaling targets, paving the way for future therapeutic strategies to combat conditions like osteoarthritis and osteoporosis.
      2025, 12(5): 764-787. DOI: 10.1186/s40779-024-00544-5
      Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family
        
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      COMMENTARY

    • The emerging role of Panx1 as a potential therapeutic target for chronic pain AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(5): 807-809. DOI: 10.1186/s40779-024-00549-0
        
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    • Mitochondrial complex I: the key to sustained microglia activation and neuroinflammation maintenance AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(5): 810-812. DOI: 10.1186/s40779-024-00554-3
        
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