FDA-approved cannabidiol [Epidiolex<sup>®</sup>] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

Maheedhar Kodali; Leelavathi N. Madhu; Venkata Sai Vashishta Kolla; Sahithi Attaluri; Charles Huard; Yogish Somayaji; Bing Shuai; Chase Jordan; Xiaolan Rao; Sanath Shetty; Ashok K. Shetty

doi:10.1186/s40779-024-00563-2

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FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

RESEARCH | Updated：2025-12-13

- FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
- FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
- “在一项关于慢性海湾战争疾病的研究中，FDA批准的CBD Epidiolex®被发现可以缓解慢性GWI大鼠的认知和情绪障碍以及痛觉过敏。这些改善归因于CBD抑制使慢性神经炎症持续存在的信号通路的能力。”
- MMR 2025年12卷第6期页码：852-874
- Affiliations：
  
  Institute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Health Science Center School of Medicine, College Station, TX 77843, USA
- Author bio：
  
  * ash.shetty@tamu.edu
- Funds：
  
  grants from Jazz Pharmaceuticals Inc.;the Texas A&M University of School of Medicine to AKS
- DOI：10.1186/s40779-024-00563-2
  中图分类号：
- 纸质出版：2025-06
- Accepted：
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FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis[J]. MMR, 2025,12(6):852-874.

Cite this article as: Kodali M, Madhu LN, Kolla VSV, Attaluri S, Huard C, Somayaji Y, et al. FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis. Mil Med Res. 2024;11(1):61.
FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis[J]. MMR, 2025,12(6):852-874. DOI： 10.1186/s40779-024-00563-2.

Cite this article as: Kodali M, Madhu LN, Kolla VSV, Attaluri S, Huard C, Somayaji Y, et al. FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis. Mil Med Res. 2024;11(1):61. DOI： 10.1186/s40779-024-00563-2.

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FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

DOI：10.1186/s40779-024-00563-2

FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis

FDA-approved cannabidiol [Epidiolex^®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis