Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

Giorgio Noera; Alfio Bertolini; Laura Calzà; Mercedes Gori; Annalisa Pitino; Graziella D’Arrigo; Colin Gerard Egan; Giovanni Tripepi

doi:10.1186/s40779-024-00555-2

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Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

RESEARCH | Updated：2025-12-13

- Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
- Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
- “在心血管外科领域，针对黑皮质素受体（MCR）的二十四碳交酯（TCS10）的3期试验表明，30天死亡率显著提高，输血次数减少。使用朴素贝叶斯分类器和基于密度的敏感性指数进行专家敏感性分析，为改善危重患者的手术救援结果提供了新的方向。”
- MMR 2025年12卷第6期页码：836-851
- Affiliations：
  
  1.Health Ricerca e Sviluppo, Global Contractor for STOPSHOCK National Plan of Military Research Ministry of Defence, Rome 00187, Italy
  2.Department of Medicine and Division of Clinical Pharmacology, School of Medicine, UNIMORE, Policlinico, Modena 41124, Italy
  3.IRET Foundation, Ozzano Dell’ Emilia, Bologna 40064, Italy
  4.Institute of Clinical Physiology (IFC-CNR), Section of Rome, Rome 00185, Italy
  5.National Research Council-Institute of Clinical Physiology, Reggio Calabria 89124, Italy
  6.CE Medical Writing SRLS, Pisa 56021, Italy
- Author bio：
  
  * giorgio.noera@gmail.com
- Funds：
  
  For global contractor, Health Ricerca e Sviluppo(NATO Commercial and Government Entity Code: AR054);the National Plan Military Research(EF a2011.188)
- DOI：10.1186/s40779-024-00555-2
  中图分类号：
- 纸质出版：2025-06
- Accepted：
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Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial[J]. MMR, 2025,12(6):836-851.

Cite this article as: Noera G, Bertolini A, Calzà L, Gori M, Pitino A, D’Arrigo G, et al. Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial. Mil Med Res. 2024;11(1):56.
Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial[J]. MMR, 2025,12(6):836-851. DOI： 10.1186/s40779-024-00555-2.

Cite this article as: Noera G, Bertolini A, Calzà L, Gori M, Pitino A, D’Arrigo G, et al. Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial. Mil Med Res. 2024;11(1):56. DOI： 10.1186/s40779-024-00555-2.

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Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

Effect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial

DOI：10.1186/s40779-024-00555-2