TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

Yi Zhuo; Wen-Shui Li; Wen Lu; Xuan Li; Li-Te Ge; Yan Huang; Qing-Tao Gao; Yu-Jia Deng; Xin-Chen Jiang; Zi-Wei Lan; Que Deng; Yong-Heng Chen; Yi Xiao; Shuo Lu; Feng Jiang; Zuo Liu; Li Hu; Yu Liu; Yu Ding; Zheng-Wen He; De-An Tan; Da Duan; Ming Lu

doi:10.1186/s40779-024-00550-7

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TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

RESEARCH | Updated：2025-12-13

- TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients
- TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients
- “在帕金森病治疗领域，研究人员取得了重大进展。他们发现，缺氧预处理的嗅粘膜间充质干细胞（hOM-MSCs）分泌的转化生长因子β1（TGF-β1）在调节多巴胺能神经元线粒体功能恢复中起着关键作用，为PD研究提供了新的方向。”
- MMR 2025年12卷第5期页码：686-715
- Affiliations：
  
  1.Hunan Provincial Key Laboratory of Neurorestoratology, 921 Hospital of Joint Logistics Support Force People’s Liberation Army of China (the Second Affiliated Hospital of Hunan Normal University), Changsha 410003, China
  2.Department of Neurosurgery, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha 410000, China
  3.National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, China
  4.Department of Neurology, the Second Xiangya Hospital, Central South University, Changsha 410013, China
  5.NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China
  6.First Clinical Department of Changsha Medical University, Changsha 410219, China
- Author bio：
  
  * Tandean20230515@163.com
  duanda1983@foxmail.com
  lumingcs163@126.com
- Funds：
  
  the Key Research and Development Program of Hunan Province of China(2020SK2102);the Hunan Provincial Natural Science Foundation of China(2023JJ40420);the Changsha Municipal Natural Science Foundation(kq2208154);the Scientific Research Project of Hunan Provincial Health Commission(B202304088074);the Scientific Research Project of Hunan Provincial Health Commission(202203105045);the National Natural Science Foundation of China(82301435;82201484);the Hunan Provincial Natural Science Foundation of China(2024JJ4083);the Graduate Research and Innovation Project of Hunan Education Department(CX20220528)
- DOI：10.1186/s40779-024-00550-7
  中图分类号：
- 纸质出版：2025-05
- Accepted：
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TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients[J]. MMR, 2025,12(5):686-715.

Cite this article as: Zhuo Y, Li WS, Lu W, Li X, Ge LT, Huang Y, et al. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients. Mil Med Res. 2024;11(1):48.
TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients[J]. MMR, 2025,12(5):686-715. DOI： 10.1186/s40779-024-00550-7.

Cite this article as: Zhuo Y, Li WS, Lu W, Li X, Ge LT, Huang Y, et al. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients. Mil Med Res. 2024;11(1):48. DOI： 10.1186/s40779-024-00550-7.

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TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients

DOI：10.1186/s40779-024-00550-7