Hippocampal PACAP signaling activation triggers a rapid antidepressant response

Hai-Lou Zhang; Yan Sun; Zhang-Jie Wu; Ying Yin; Rui-Yi Liu; Ji-Chun Zhang; Zhang-Jin Zhang; Suk-Yu Yau; Hao-Xin Wu; Ti-Fei Yuan; Li Zhang; Miroslav Adzic; Gang Chen

doi:10.1186/s40779-024-00548-1

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Hippocampal PACAP signaling activation triggers a rapid antidepressant response

RESEARCH | Updated：2025-12-13

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- Hippocampal PACAP signaling activation triggers a rapid antidepressant response
- “Reporting on the cutting-edge research in rapid antidepressant mechanisms, a study delves into the role of the neuropeptide PACAP in mediating swift responses to depression treatment. The research, involving 446 mice and various behavioral and molecular assays, reveals that activating hippocampal PACAP signaling triggers a rapid antidepressant effect by modulating CaMKⅡ inhibition-governed eEF2-mTOR-BDNF signaling, offering a new therapeutic approach for depression.”
- Hai-Lou Zhang , Yan Sun , Zhang-Jie Wu , Ying Yin , Rui-Yi Liu , Ji-Chun Zhang , Zhang-Jin Zhang , Suk-Yu Yau , Hao-Xin Wu , Ti-Fei Yuan , Li Zhang , Miroslav Adzic , Gang Chen
- Military Medical Research Vol. 12, Issue 4, Pages: 512-527(2025)
- Affiliations：
  1.Interdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou 510632, China
  2.Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou 510632, China
  3.The Guangdong-Hongkong-Macau Joint Laboratory of Traditional Chinese Medicine Regulation of Brain-Periphery Homeostasis and Comprehensive Health, Guangzhou 510632, China
  4.Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
  5.School of Medicine, Jinan University, Guangzhou 510632, China
  6.School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China
  7.Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong 999077, China
  8.Shanghai Mental Health Center, Shanghai 200030, China
  9.Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
  10."Vinča" Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology 090, University of Belgrade, 11001 Belgrade, Serbia
- Author bio：
  *chengang@jnu.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00548-1
  CLC：
- Accepted：
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Hippocampal PACAP signaling activation triggers a rapid antidepressant response

DOI： 10.1186/s40779-024-00548-1

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