Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

Yi-Min Cai; Ze-Qun Lu; Bin Li; Jin-Yu Huang; Ming Zhang; Can Chen; Lin-Yun Fan; Qian-Ying Ma; Chun-Yi He; Shuo-Ni Chen; Yuan Jiang; Yan-Min Li; Cai-Bo Ning; Fu-Wei Zhang; Wen-Zhuo Wang; Yi-Zhuo Liu; Heng Zhang; Meng Jin; Xiao-Yang Wang; Jin-Xin Han; Zhen Xiong; Ming Cai; Chao-Qun Huang; Xiao-Jun Yang; Xu Zhu; Ying Zhu; Xiao-Ping Miao; Shao-Kai Zhang; Yong-Chang Wei; Jian-Bo Tian

doi:10.1186/s40779-024-00539-2

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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

RESEARCH | Updated：2025-12-13

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- Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
- “In the field of cancer research, a comprehensive analysis of enhancer RNA quantitative trait loci (eRNAQTLs) was conducted, identifying 300,112 eRNAQTLs across 30 cancer types. Expert established the CancereRNAQTL system, which provides solutions to solve cancer heritability problems and lays a foundation for the construction of eRNA-based therapeutic strategies.”
- Yi-Min Cai , Ze-Qun Lu , Bin Li , Jin-Yu Huang , Ming Zhang , Can Chen , Lin-Yun Fan , Qian-Ying Ma , Chun-Yi He , Shuo-Ni Chen , Yuan Jiang , Yan-Min Li , Cai-Bo Ning , Fu-Wei Zhang , Wen-Zhuo Wang , Yi-Zhuo Liu , Heng Zhang , Meng Jin , Xiao-Yang Wang , Jin-Xin Han , Zhen Xiong , Ming Cai , Chao-Qun Huang , Xiao-Jun Yang , Xu Zhu , Ying Zhu , Xiao-Ping Miao , Shao-Kai Zhang , Yong-Chang Wei , Jian-Bo Tian
- Military Medical Research Vol. 12, Issue 4, Pages: 488-511(2025)
- Affiliations：
  1.Department of Epidemiology and Biostatistics, School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Tai-Kang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China
  2.Department of Gastrointestinal Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China
  3.Department of Cancer Epidemiology, Henan Engineering Research Center of Cancer Prevention and Control, Henan International Joint Laboratory of Cancer Prevention, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China
  4.Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  5.Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  6.Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China
  7.Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
  8.Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  9.Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China
  10.Department of Gastrointestinal Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
- Author bio：
  *xpmiao@whu.edu.cn;
  shaokaizhang@126.com;
  weiyongchang@whu.edu.cn;
  tianjb@whu.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00539-2
  CLC：
- Accepted：
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Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

DOI： 10.1186/s40779-024-00539-2

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