Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

Liu-Xi Chu; Wen-Jia Wang; Xin-Pei Gu; Ping Wu; Chen Gao; Quan Zhang; Jia Wu; Da-Wei Jiang; Jun-Qing Huang; Xin-Wang Ying; Jia-Men Shen; Yi Jiang; Li-Hua Luo; Jun-Peng Xu; Yi-Bo Ying; Hao-Man Chen; Ao Fang; Zun-Yong Feng; Shu-Hong An; Xiao-Kun Li; Zhou-Guang Wang

doi:10.1186/s40779-024-00537-4

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Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

REVIEW | Updated：2025-12-13

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- Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
- “In the field of aging and regeneration research, spatiotemporal multi-omics approaches have made significant progress. Expert researchers have established the spatiotemporal multi-omics system, which provides solutions to solve the problems of molecular dynamics, cellular interactions, and signaling pathways in aging and regeneration research.”
- Liu-Xi Chu , Wen-Jia Wang , Xin-Pei Gu , Ping Wu , Chen Gao , Quan Zhang , Jia Wu , Da-Wei Jiang , Jun-Qing Huang , Xin-Wang Ying , Jia-Men Shen , Yi Jiang , Li-Hua Luo , Jun-Peng Xu , Yi-Bo Ying , Hao-Man Chen , Ao Fang , Zun-Yong Feng , Shu-Hong An , Xiao-Kun Li , Zhou-Guang Wang
- Military Medical Research Vol. 12, Issue 4, Pages: 528-566(2025)
- Affiliations：
  1.Affiliated Cixi Hospital, Wenzhou Medical University, Ningbo 315300, Zhejiang, China
  2.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China
  3.National Key Laboratory of Macromolecular Drug Development and Manufacturing, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China
  4.State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China
  5.School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China
  6.Department of Human Anatomy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, Shandong, China
  7.Integrative Muscle Biology Laboratory, Division of Regenerative and Rehabilitative Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, United States
  8.Key Laboratory for Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, Zhejiang, China
  9.Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Hospital of Zhejiang University, Lishui 323000, Zhejiang, China
  10.School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 324025, Zhejiang, China
  11.Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore
  12.Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore
  13.Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
  14.Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore 138673, Singapore
- Author bio：
  *230198401@aa.seu.edu.cn;
  shha@sdfmu.edu.cn;
  xiaokunli@wmu.edu.cn;
  wangzhouguang@wmu.edu.cn
- Funds：
- DOI： 10.1186/s40779-024-00537-4
  CLC：
- Accepted：
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Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

DOI： 10.1186/s40779-024-00537-4

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