Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

RESEARCH | Updated：2025-12-13

- Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
- “In the field of liver ischemia/reperfusion injury, this study introduces its research progress. Expert xx verified the conjecture that interferon-α stimulates DHX58 to promote the translation of m6A-modified Gpx4 mRNA, which provides solutions to prevent hepatic ferroptosis during liver I/R injury.”
- Kai-Wei Jia , Ren-Qi Yao , Yi-Wen Fan , Ding-Ji Zhang , Ye Zhou , Min-Jun Wang , Li-Yuan Zhang , Yue Dong , Zhi-Xuan Li , Su-Yuan Wang , Mu Wang , Yun-Hui Li , Lu-Xin Zhang , Ting Lei , Liang-Chen Gui , Shan Lu , Ying-Yun Yang , Si-Xian Wang , Yi-Zhi Yu , Yong-Ming Yao , Jin Hou
- Military Medical Research Vol. 12, Issue 2, Pages: 184-203(2025)
- Affiliations：
  1.National Key Laboratory of Medical Immunology & Institute of Immunology, Naval Medical University, Shanghai 200433, China
  2.Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  3.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100853, China
  4.Center for Immunotherapy, Chinese Academy of Medical Sciences, Beijing 100005, China
- Author bio：
  *c_ff@sina.com;
  houjin@immunol.org
- Funds：
- DOI： 10.1186/s40779-024-00524-9
  CLC：
- Accepted：
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