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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
RESEARCH | Updated：2025-12-13
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    • Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

    • “In the field of mechanical pain research, the KIF5B/EndoA2/Piezo2 complex is essential for Piezo2 trafficking and sustaining transmission of touch and mechanical hypersensitivity signals. Expert EndoA2 regulates touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking in sensory neurons, which provides a potential new target for the treatment of mechanical pain.”
    • Man-Xiu Xie , Ren-Chun Lai , Yi-Bin Xiao , Xi Zhang , Xian-Ying Cao , Xiao-Yu Tian , An-Nan Chen , Zi-Yi Chen , Yan Cao , Xiao Li , Xiao-Long Zhang
    • Military Medical Research Vol. 12, Issue 2, Pages: 157-183(2025)

    • DOI： 10.1186/s40779-024-00520-z     

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