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ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis
RESEARCH | Updated：2026-08-21
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    • ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

    • “A research team reveals the ZBP1-STAT3-LGMN signaling axis driving Klebsiella pneumoniae sepsis, establishing that macrophage ZBP1 suppresses anti-inflammatory LGMN through STAT3 inhibition. Expert genetic and myeloid-specific knockout models verified that targeting ZBP1 or restoring LGMN activity reduces cytokine production and improves survival, which provides solutions to treat severe bacterial infections and lay a foundation for the construction of sepsis immunotherapy.”
    • Li-Ting Deng , Huan Yang , Xu-Fei Zhang , Ze-Xing Lin , Ni Kuang , Hai-Yang Jiang , Pei-Zhao Liu , Yang-Guang Li , Xuan-Heng Li , Wei-Zhen Li , Chu-Jun Ni , Ming-Jie Qiu , Yue Chao , Yu-Fei Pan , Yi-Yu Yang , Ye-Ting Zhu , Yun Zhao , Jian-An Ren , Xiu-Wen Wu
    • Military Medical Research (2026)

    • DOI： 10.1016/j.mmr.2026.100059     

      CLC：

    • Accepted：24 July 2026 ，

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