RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

Rui Xiang; Wen-Jun Liu; Xin-Rui Zhang; Han Yan; Xin Li; Song Hou; Cheng-Qing Hu; Yun-Tao Hu; Ru-Feng Ma; Jing Li; Yu-Jing Chi; Qing-Hua Cui; Zhen-Zhen Chen; Bin Geng; Ji-Chun Yang

doi:10.1016/j.mmr.2026.100056

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RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

RESEARCH | Updated：2026-08-21

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- RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch
- “Researchers identified RIMKLA as a key regulator of hypertension, establishing that this scaffold protein recruits PTP1B and PKM2 to drive vascular smooth muscle cell phenotype switch through glucose metabolism reprogramming, which opens up a new direction for targeted antihypertensive therapy development.”
- Rui Xiang , Wen-Jun Liu , Xin-Rui Zhang , Han Yan , Xin Li , Song Hou , Cheng-Qing Hu , Yun-Tao Hu , Ru-Feng Ma , Jing Li , Yu-Jing Chi , Qing-Hua Cui , Zhen-Zhen Chen , Bin Geng , Ji-Chun Yang
- Military Medical Research (2026)
- Affiliations：
  Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  Department of Pathophysiology, School of Basic Medical Sciences and Public Health, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Medical Department, Jiangsu University, Zhenjiang 212013, Jiangsu, China
  Department of Physiology, School of Basic Medical Science, Kunming Medical University, Kunming 650500, China
  Department of Endocrinology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China
  Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology, State Key Laboratory of Female Fertility Promotion, Beijing 100191, China
  Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
  Department of Central Laboratory and Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, China
  Department of Biomedical Informatics, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing 100191, China
  Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China
  State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, CAMS & PUMC, Beijing 102308, China
  Department of Cardiology, Peking University Third Hospital, Beijing 100191, China
- Author bio：
  *Qing-Hua Cui, cuiqinghua@bjmu.edu.cn;
  Zhen-Zhen Chen, chenzhenzhen@bjmu.edu.cn;
  Bin Geng, bingeng@hsc.pku.edu.cn;
  Ji-Chun Yang, yangj@bjmu.edu.cn
- Funds：
- DOI： 10.1016/j.mmr.2026.100056
  CLC：
- Accepted：20 July 2026 ，
- Accepted：
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RIMKLA promotes hypertension by activating PKM2 to trigger VSMC phenotype switch

DOI： 10.1016/j.mmr.2026.100056

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