Downregulation of FTO aggravates osteoarthritis with obesity by erasing m6A methylation of PDP2

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Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

RESEARCH | Updated：2026-08-21

- Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2
- “A new study reveals FTO gene downregulation drives obesity-related osteoarthritis progression through the FTO/YTHDF2/PDP2 axis, offering promising therapeutic targets for this degenerative joint disease.”
- Xu-Ying Sun , Jing-Yue Su , Xin Chen , Yi-Xin Yang , Sheng-Wu Yang , Chun-Wu Zhang , Yu-Sheng Li , Jian Xu , Zhen-Han Deng
- Military Medical Research (2026)
- Affiliations：
  Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  Department of Orthopedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Geriatrics Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Department of Epidemiology, University of California, Los Angeles, CA 90095, USA
  Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
  Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- Author bio：
  Jian Xu, 0022029@zju.edu.cn
  *Zhen-Han Deng, dengzhenhan@wmu.edu.cn;
- Funds：
- DOI： 10.1016/j.mmr.2026.100054
  CLC：
- Accepted：09 July 2026 ，
- Accepted：
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