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Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
Dual-locked targeted alpha-emitter enhanced tumor immunotherapy via Diels–Alder reaction-based self-immolative molecular cage strategy
- “Researchers developed a dual-locked pretargeted strategy integrating platinumIV-loaded hydrogel nanoparticles and radium-223-loaded nanoparticles into an inverse electron demand Diels–Alder-activated drug delivery system, which provides solutions to solve the critical challenge of radionuclide leakage in targeted alpha therapy and lay a foundation for the construction of next-generation precision-targeted radiopharmaceuticals.”
- Military Medical Research Vol. 13, Issue 5, Pages: 728-746(2026)
DOI： 10.1186/s40779-025-00673-5
Accepted：13 November 2025
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