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TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice
RESEARCH | Updated：2026-06-10
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    • TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

    • “A research team introduces its progress in liver fibrosis treatment. They engineered TNC-targeted CAR-macrophages, verified their ability to engulf activated hepatic stellate cells and reduce fibrosis via TLR4/NF-κB and integrin/FAK pathways, which provides solutions for liver disease therapy.”
    • Kai-Zhao Chen , Zi-Yang Lin , Long-Jun Chen , You-Xi Zhou , Wei Zhang , Hao-Yang Wan , Yong-Kun Huo , Qi Fu , Zi-Qing Gao , Hong-Wei Cheng , Xiao-Dong Ma , Shuai-Shuai Zhang
    • Military Medical Research Vol. 13, Issue 5, Pages: 706-727(2026)

    • DOI： 10.1186/s40779-025-00667-3     

      CLC：

    • Accepted：31 October 2025 ，

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