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Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia
RESEARCH | Updated：2025-12-13
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    • Salmonella enterica mediated epigenetic promotion of fibrosis is a novel factor in benign prostatic hyperplasia

    • “Reporting on the latest research in the field of benign prostatic hyperplasia (BPH), experts have established a novel link between microbial presence and prostatic fibrosis. The study, which provides solutions to address the ineffectiveness of current BPH treatments, verified that Salmonella enterica promotes prostatic fibrosis through ALKBH5-m6A-GPX4-mediated ferroptosis, laying a foundation for the construction of new therapeutic targets and personalized strategies.”
    • Cong Zhu , Lu-Yao Li , Ming-Hui Shi , Cheng Fang , Lu Yang , Ting Li , Fei Li , Shi-Song Yang , Tian-Kun Wang , Dao-Jing Ming , Tong Deng , Hao-Yue Sun , Wen-Ting Li , Jia Zhang , Yu-Sen Zhang , Zhi-Yuan Jian , Chang-Jiang Qin , Shuang-Ying Wang , Xian-Tao Zeng
    • Military Medical Research Vol. 12, Issue 9, Pages: 1350-1368(2025)

    • DOI： 10.1186/s40779-025-00614-2     

      CLC：

    • Accepted：29 April 2025 ，

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Related Author

Xian-Tao Zeng
Shuang-Ying Wang
Chang-Jiang Qin
Zhi-Yuan Jian
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Tong-Zu Liu
Hang Zheng

Related Institution

Department of Urology, Institute of Urology, Peking University First Hospital, Peking University, The National Urological Cancer Center of China
Evidence-Based Medicine Center, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine
Department of Urology, Wuhan Clinical Research Center of Tumors of the Urinary System and Male Genital Organs, Hubei Key Laboratory of Urinary System Diseases, Zhongnan Hospital of Wuhan University
Department of Urology, Wuhan Third Hospital, Tongren Hospital of Wuhan University
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