Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

Guo-Lin Miao; Wen-Xi Zhang; Yi-Tong Xu; Yi-Ran Liu; Ping-Ping Lai; Jia-Bao Guo; Gong-Lie Chen; Jing-Xuan Chen; Zi-Hao Zhou; Yan-Wei Li; Chong Zhang; Yang Ding; Lian-Xin Zhang; Yu-Fei Han; Jin-Xuan Chen; Jing-Dong Wu; Yin-Qi Zhao; Si Mei; Yang Zhao; Yuan-Wu Ma; Ling Zhang; Wei Huang; Dong-Yu Zhao; Er-Dan Dong; Yu-Hui Wang; Xun-De Xian

doi:10.1186/s40779-025-00594-3

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Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

RESEARCH | Updated：2025-12-13

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- Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease
- “In the field of metabolic dysfunction-associated fatty liver disease (MAFLD), researchers have established a causal relationship between KIF13B deficiency and MAFLD, laying a foundation for the construction of a potential therapeutic target for treating MAFLD.”
- Guo-Lin Miao , Wen-Xi Zhang , Yi-Tong Xu , Yi-Ran Liu , Ping-Ping Lai , Jia-Bao Guo , Gong-Lie Chen , Jing-Xuan Chen , Zi-Hao Zhou , Yan-Wei Li , Chong Zhang , Yang Ding , Lian-Xin Zhang , Yu-Fei Han , Jin-Xuan Chen , Jing-Dong Wu , Yin-Qi Zhao , Si Mei , Yang Zhao , Yuan-Wu Ma , Ling Zhang , Wei Huang , Dong-Yu Zhao , Er-Dan Dong , Yu-Hui Wang , Xun-De Xian
- Military Medical Research Vol. 12, Issue 9, Pages: 1329-1349(2025)
- Affiliations：
  1.Institute of Cardiovascular Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  2.Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100191, China
  3.Department of Biomedical Informatics, State Key Laboratory of Vascular Homeostasis and Remodeling, School of Basic Medical Sciences, Peking University, Beijing 100191, China
  4.Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang 110134, China
  5.State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education, Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing 100871, China
  6.Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medicine College, Beijing 100021, China
  7.Research Center for Cardiopulmonary Rehabilitation, University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital), School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, Shandong, China
  8.Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University Third Hospital, Beijing 100191, China
- Author bio：
  * Dong-Yu Zhao zhaodongyu@bjmu.edu.cn
  Er-Dan Dong donged@bjmu.edu.cn
  Yu-Hui Wang wangyuhui2009@bjmu.edu.cn
  Xun-De Xian xianxunde@bjmu.edu.cn
- Funds：
- DOI： 10.1186/s40779-025-00594-3
  CLC：
- Accepted：16 January 2025 ，
- Accepted：
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Motor protein KIF13B orchestrates hepatic metabolism to prevent metabolic dysfunction-associated fatty liver disease

DOI： 10.1186/s40779-025-00594-3

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