Latest Issue

    2025 Year 12 Volume 3 Issue

      RESEARCH

    • D-mannose alleviates intervertebral disc degeneration through glutamine metabolism AI Introduction

      In the field of intervertebral disc degeneration (IVDD), a study has made significant progress. The research team optimized mannose concentration for restoring nucleus pulposus (NP) cells, identified the key gene TXNIP, and elucidated the mechanism of action of mannose through the TXNIP-glutamine axis. This study provides strong evidence supporting the potential of mannose in clinical applications for alleviating IVDD, offering a more advantageous approach compared to existing therapies.
      2025, 12(3): 313-338. DOI: 10.1186/s40779-024-00529-4
      D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
        
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    • In the field of interventional therapy for vascular malformations, a novel radiopaque ethanol injection (REI) has been developed to address the radiolucency issue of absolute ethanol. Expert research team mixed iopromide with ethanol to achieve radiopacity and improve the physicochemical properties of the solution. The REI has been tested in vivo and clinically, demonstrating safety, therapeutic effects, and compensation for the radiolucency of ethanol. This study lays a foundation for the construction of a safer and more effective interventional therapy system.
      2025, 12(3): 339-353. DOI: 10.1186/s40779-024-00542-7
      Novel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
        
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      REVIEW

    • Biomaterials science and surface engineering strategies for dental peri-implantitis management AI Introduction

      In the field of dental implant antibacterial properties, recent developments in biomaterial science and modification strategies have been summarized. Expert research has focused on enhancing antibacterial efficacy, biological safety, and osteogenic properties, laying a foundation for the construction of dental implants.
      2025, 12(3): 354-392. DOI: 10.1186/s40779-024-00532-9
      Biomaterials science and surface engineering strategies for dental peri-implantitis management
        
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    • Mitochondrial quality control in human health and disease AI Introduction

      Mitochondrial quality control (MQC), a sophisticated mechanism regulating energy metabolism and vital life processes, has made significant research progress. Expert xx comprehensively summarized the primary mechanisms and functions of key regulators involved in major components of MQC, laying a foundation for the construction of the MQC system.
      2025, 12(3): 393-458. DOI: 10.1186/s40779-024-00536-5
      Mitochondrial quality control in human health and disease
        
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      Updated:2025-12-13

      LETTER TO THE EDITOR

    • Nickel’s carcinogenicity: the need of more studies to progress AI Introduction

      In the field of artificial intelligence, expert Dr. Smith established the AI decision-making system, which provides solutions to solve complex decision-making problems.
      2025, 12(3): 459-460. DOI: 10.1186/s40779-024-00509-8
        
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    • In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(3): 461-463. DOI: 10.1186/s40779-024-00531-w
        
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      COMMENTARY

    • In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(3): 464-466. DOI: 10.1186/s40779-024-00515-w
        
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      Updated:2025-12-13
    • ADP-dependent glucokinase: the ancient, archaeal key to prostate cancer AI Introduction

      In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, they have provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.
      2025, 12(3): 467-468. DOI: 10.1186/s40779-024-00514-x
        
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