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D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
RESEARCH | Updated:2025-12-13
    • D-mannose alleviates intervertebral disc degeneration through glutamine metabolism

    • D-mannose alleviates intervertebral disc degeneration through glutamine metabolism

    • 在椎间盘退变(IVDD)领域,一项研究取得了重大进展。研究小组优化了甘露糖浓度以恢复髓核(NP)细胞,鉴定了关键基因TXNIP,并通过TXNIP谷氨酰胺轴阐明了甘露糖的作用机制。这项研究提供了强有力的证据,支持甘露糖在临床应用中缓解IVDD的潜力,与现有疗法相比,提供了一种更有利的方法。
    • MMR   2025年12卷第3期 页码:313-338
    • DOI:10.1186/s40779-024-00529-4    

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    • 纸质出版:2025-03

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  • D-mannose alleviates intervertebral disc degeneration through glutamine metabolism[J]. MMR, 2025,12(3):313-338. DOI: 10.1186/s40779-024-00529-4.

    Cite this article as: Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, Wang Y, et al. D-mannose alleviates intervertebral disc degeneration through glutamine metabolism. Mil Med Res. 2024;11(1):28. DOI: 10.1186/s40779-024-00529-4.

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Heng-Zhen Li
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Department of Orthopedics, Xiangya Hospital, Central South University
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