Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

Tong-Zhou Liang; Zhe-Yu Jin; Yue-Jun Lin; Zi-Yi Chen; Ye Li; Jian-Kun Xu; Fan Yang; Ling Qin

doi:10.1186/s40779-025-00600-8

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Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

REVIEW | Updated：2025-12-13

- Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies
- Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies
- “在骨研究领域，本文回顾了神经系统与骨代谢之间的联系，无论是完整的还是损伤后的。它探讨了特定脑核与骨稳态之间的关系、骨神经支配和神经亚型的特征，以及这些神经的分子特征和调节功能。本文还总结了利用神经功能改善骨稳态和促进骨再生的可用转化方法。”
- Military Medical Research 2025年12卷第10期页码：1645-1666
- Affiliations：
  
  1.Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China
  2.Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China
  3.The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, China
  4.Areas of Excellence Centre for Musculoskeletal Degeneration and Regeneration, Sha Tin 999077, Hong Kong, China
- Author bio：
  
  * Jian-Kun Xu jiankunxu@cuhk.edu.hk
  Fan Yang fan.yang@siat.ac.cn
  Ling Qin lingqin@cuhk.edu.hk
- Funds：
  
  the Health & Medical Research Fund(18190481);the General Research Fund(14120520)
- DOI：10.1186/s40779-025-00600-8
  中图分类号：
- 收稿：2024-10-02，
  
  录用：2025-03-04，
  
  网络首发：2025-03-20，
  
  纸质出版：2025-10
- Accepted：
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Tong-Zhou Liang, Zhe-Yu Jin, Yue-Jun Lin, 等. Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies[J]. Military Medical Research, 2025,12(10):1645-1666.

Tong-Zhou Liang, Zhe-Yu Jin, Yue-Jun Lin, et al. Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies[J]. Military Medical Research, 2025, 12(10): 1645-1666.
Tong-Zhou Liang, Zhe-Yu Jin, Yue-Jun Lin, 等. Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies[J]. Military Medical Research, 2025,12(10):1645-1666. DOI： 10.1186/s40779-025-00600-8.

Tong-Zhou Liang, Zhe-Yu Jin, Yue-Jun Lin, et al. Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies[J]. Military Medical Research, 2025, 12(10): 1645-1666. DOI： 10.1186/s40779-025-00600-8.

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Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

Targeting the central and peripheral nervous system to regulate bone homeostasis:mechanisms and potential therapies

DOI：10.1186/s40779-025-00600-8