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Volume 28 ， Issue 2 ， 2013
- Abstract：Objective:Assessment of digestion colonic flora lactulose can be induced to produce hydrogen and prove lactulose with a potential anti-inflammatory effects. Methods:We established a mouse model of human ulcerative colitis （UC） by supplying mice with water containing dextran sulfate sodium （DSS）. At 7-day, DSS-induced pathogenic outcomes, including loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of TNF-α, IL-1β, malondialdehyde （MDA） and myeloperoxidase （MPO） deficiency in colon lesions, were significantly suppressed by lactulose administration and intraperitoneally injected hydrogen water. Results:After eliminating colon microflora by antibiotics, the anti-inflammatory effects of lactulose were significantly compromised. Histological analysis also revealed that the DSS mediated colonic tissue destruction accompanied by neutrophils infiltration was remarkably suppressed by lactulose and hydrogen water. Conclusion:The present study indicated that lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress state in colitis.2|13|1Updated：2026-03-12
- Abstract：Objective:To investigate the significance of bone mineral changes in the pathogenic process of steroid-induced osteonecrosis in rabbits. Methods:Seventy adult female Japanese White rabbits were randomly divided into five groups. Animals in steroid group received an intramuscular injection of methylprednisolone acetate （4 mg/kg） once a week, and killed in four different time after first treatment. Animals in control group received an intramuscular injection with the same volume of normal saline, while 150 kU penicillin was injected twice a week for preventing infection in all groups. The contents of serum calcium （Ca） and phosphorus （P） were determined and the bone mineral densities of the femoral head and neck were measured at the 2nd, 4th, 8th and 10th weeks after first treatment. Meanwhile the general condition such as weight, spirit and hair of rabbits was observed. Results:Compared with the control group, the weight of rabbits in steroid group lost since the first week, and progressively aggravated; the bone mineral density of the femoral head and neck was lowered since the 2nd and 4th week respectively （P<0.05, P<0.01）, and lowered more quickly in femoral neck than in femoral head. In steroid group, the bone mineral density of the femoral neck at the 10th week was significantly lower than that at the 8th week （P<0.05）. Compared with the control group, the serum levels of Ca and P in steroid group were lowered since the 2nd week （P<0.05, P<0.01）. In steroid group, the serum Ca level at the 10th week was lower than that at the 8th week, and the serum P level waslowered more quickly than Ca level was. Conclusion:Osteonecrosis appears in rabbits shortly after corticoids are first administered, and osteonecrosis in rabbits is chronologically associated with the onset of hypocalcaemia, hypophosphatemia and lowered bone mineral density. Steroid-induced osteonecrosis may be relevant to bone mineral loss and density lowering of the femoral head and neck.2|24|0Updated：2026-03-12
- Abstract：Objective:To observe the electrocardiogram （ECG） and heart rate in a rabbit model of hyperkalemia induced by potassium chloride, and provide theoretical and experimental reference for timely diagnosis of hyperkalemia clinically. Methods:Forty rabbits were randomly assigned into four groups. 0.9% isotonic saline solution was perfused in the groupⅠ, while l.0%, 4.0% and 10.0% potassium chloride solutions were perfused in the other groups, respectively, to induce hyperkalemia. Results:The changes of serum potassium, ECG and heart rate before perfusion were significantly （P<0.05） different from those after perfusion in the other groups compared with groupⅠ. The effect of ECG variability rates was well consistent （Kappa=0.724, P<0.01） with that of serum potassium on diagnostic tests in the other groups. The area under ROC curve in diagnosis effect of ECG variability rates and serum potassium on hyperkalaemia was much significantly larger （P<0.01 and P<0.05） compared with 0.5. There was asignificantly positive correlation between ECG variability rates and serum potassium （r=0.865, P<0.05 for bilateral Pearson test）. There was certain positive correlation between heart rate and serum potassium, but the correlation was poor （r= 0.526, R 2 =0.277）. Conclusion:A combination of serum potassium, ECG variability rates and heart rate should be considered and analyzed by synthesis to establish an accurate and timely diagnosis for hyperkalemia.2|37|0Updated：2026-03-12
- Abstract：Objective:A novel portable and intelligent fluid resuscitation infuser is proposed in this paper. It satisfies the demands of long time use in harsh environment, such as traffic accident, natural disaster, battlefield, evacuation, pre-hospital emergency and so on. Methods:Miniature linear motor and liquid blood cartridge compose the pump body. It’s based on the biological impedance method to measure and control, which resolve the disadvantage of traditional infuser device:large power dissipation, big size, AC power supply only and can’t be use in field. The whole device weights 250 gram and sizes as two mobile phone together. Results:Model device experiment shows:six number 7 standard AAA size alkaline batteries will run the pump for approximately 8-10 h at 6 liters per hour; IV bag can be placed at any position of patient, even under the stretcher. Conclusion:It provides accurate and reliable intravenous infusion for first-aid treatment in field2|42|0Updated：2026-03-12
- Abstract：Objective:To treat and prevent auricular keloid so as to imporve the cure rate and lower the rate of recurrence. Methods:Taking 156 sufferers of auriclar keloid at the orthopaedics department of the Southwest Hospital under the Third Military Medical University from June, 2008 to June, 2011 as the research subject, this research carried out retrospective analysis and summary of different surgical methods with the clinical data of subseque nt treatments, including medicament, radiotheropy, pressure, etc. Results:There was no auricular cartilage necrosis and deformation in the total of 156 cases. It was found that 134 cases were cured in a year of postoperative follow-up, getting the care rate to 85.9%. The treatment was effective on 20 cases, with the effective rate of 12.8%, while it was ineffective on 2 cases, with the ineffective rate being 1.3%. However, two cases showed tendency towards recurrence, which were treated effectively by non-surgical methods like local hormone injection. There was neither recurrence nor apparent hyperplasia of hypertrophic scars on the rest cases, with the auricle and the earlobe in good shape. Conclusion:By auricular keloid excision and stripping surgery, surgical suture tension was reduced. Glucocorticoid and radiotherapy were instantly applied to inhibit pyperplasia of cicatrical tissue. Subsequently, pressure, anti-scarring drugs and silicone membrane were adopted to ensure fine postoperative apperance and reduce recurrence. These methods were proved to be effectiveand they provided systematic and effective treatment for auricular keloid.3|17|1Updated：2026-03-12
- Abstract：Type Ⅱ heparin-induced thrombocytopenia （HIT） is a life-threatening adverse drug reaction initiated by heparin administration. We described a rare case of LMWH-induced HIT complicated with proven pulmonary embolism （PE） in a 75-year-old male patient who hospitalized with diagnose of right knee osteoarthritis and was underwent total knee arthroplasty. The patient was successfully treated with argatroban. Early recognition and timely alternative therapy are of great importance in the treatment of this severe disorder.2|18|0Updated：2026-03-12
- Abstract：The incidence of violence against doctors has been increasing, both in China and worldwide. Very often we hear doctors being molested, thrashed and abused by lay public for a trivial medical malpractice or even no fault of theirs. The once glittering halo of medical workers is being shredded thanks to the stressed health system and a lack of evaluation for risk of violence of the patients. Modern China sees a wide disparity between industry standards in rural and urban areas. People seeking health care service are often scared, can’t get timely service and turn their anger towards those around them. To change a whole system in this giant nation is too hard a rock. Therefore, our focus is on the prompt awareness and preparation of a possible patient violence. The simplest approaches seem to be the most effective. Medical staffs should re-learn empathy on patients and be better trained on recognizing and reducing conflicts.2|22|0Updated：2026-03-12
- Abstract：The voice of calling for humanistic concern is always from uncountable doctor-patient conflicts, from which we often hear a doctor is killed or injured for disputes. Prejudice has been rooted in mind that all doctors and nurses are interest-centered and cold-blooded. To some extent, it’s true that patterned questions with a poker face are always more than gentle words with warm smile. Nurses are the ones who keep patients company for the longest time. Therefore, caring matters more for them. The explicit concept of "caring" will be introduced and we will attach great importance to how nurses can achieve caring. From the following aspects:the practices of loving kindness, the instillation of faith and hope, sensitivity to indicators of disease, improvem ent of healing environment, communication arts etc, you will understand why nurse is the symbol of angel. We can begin with caring about people around us. Our duty is not only to deal the ill but to warm the chill.2|43|3Updated：2026-03-12
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