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Volume 27 ， Issue 2 ， 2012
- Abstract：Objective:To explore whether the conventional pathologic stages of some non-small cell lung cancer （NSCLC） patients were underestimated.Methods:195 lymph node samples were taken from 25 NSCLC patients during the operations.Firstly,each resulting tissue block was processed for routine paraffin embedding.Then the 6～10 serial sections were chosen,each 5 μm thick,from every paraffin block of the lymph node.Finally,the first and the second last sections of each lymph node were stained by hematoxylin eosin （HE）,and the other serial sections were used for the immunohistochemical （IHC） staining examination with the monoclonal antibody against cyokeratin 19.Results:With HE staining,30 of the 195 regional lymph nodes revealed dominant nodal metastases,and none showed micrometastases.IHC staining was performed on 135 lymph nodes that were identified as free of metastases by HE staining,31 showed micrometastases;none showed gross nodal metastases.There was a significant difference between HE staining staging and IHC staining staging （P<0.05）.Conclusion:Conventional HE staining can accurately detect gross nodal metastases in the lymph nodes of NSCLC patients,but is unfit for detecting lymph nodal micrometastases.IHC staining analysis can significantly facilitate the detection of occult micrometastatic tumor cells in lymph nodes,and its assessment of nodal micrometastases can provide a refinement of TNM stage for NSCLC patients.Our results provide a rationale for extensive lymph nodes sampling.0|11|0Updated：2026-03-12
- Abstract：We describe the prenatal diagnosis and fetal phenotype of partial trisomy 12 （p12-pter） transmitted from a maternal reciprocal translocation 6;12.Genetic analysis of umbilical cord blood of a 27-year-old woman,gravida 4,para 1 at 35 weeks’ gestation due to a tricuspid regurgitation and orbital hypertelorism by sonography revealed an unusual karyotype of 46,XY,der （6）t（6;12）（p24;p12）mat.The pregnancy was terminated at 37 gestational weeks.The proband postnatally displayed by dysmorphic features of a round flat face with prominent cheeks and high forehead,hypertelorism,a short nose,a broad and depressed nasal bridge,anteverted nares,a deformed philtrum,an open mouth,thin upper vermilion and broad everted lower lip,low-set ears and aural atresia,broad hands with simian creases,and a short neck.By anatomy,the fetal was found to have right artery catheter vagus,congenital cataract,no turbinate and external auditory canal.Through the karoytpye-phynotpye analysis on the present patient and a review of other reported cases,we believed that the case was the first report,which expanded the database of partial trisomy 12p,and was of benefit for future clinical genetic counseling.At the same time,this study supported the viewpoint that phenotypic variability depends on the type and extent of the associated partial monosomy.0|7|0Updated：2026-03-12
- Abstract：Currently,the growing number of end-stage renal disease patients in developing countries consumes a greater proportion of healthcare budget,and increasing attention is being focused on the cost-effectiveness of the procedure.We aimed to assess the cost-effectiveness of living-related renal transplantation （RTx） as compared with that for hemodialysis （HD） and identify medical factors associated with charges for RTx in northwestern China.This study was a retrospective analysis of 372 patients on regular HD and 122 living-related kidney transplant recipients on regular follow-up for at least 3 years in northwestern China.All data on charges included HD procedure,RTx procedure,the cost for donor operation,immunosuppression,and follow-up medicare.The average annual cost to all patients on HD and kidney recipients during the first 3 years after RTx was $14482/$31027,$13502/$11038,and $13382/$10243,respectively.The three variables were found to be significant in predicting increased costs for RTx:diltiazem administration,acute rejection and infection complications.We concluded that from the second year on,RTx in China was more effective and less costly than dialysis treatment,although recipients without diltiazem administration and with acute rejection or infection proved costlier during the first year after transplantation.0|10|1Updated：2026-03-12
- Abstract：Objective:To investigate the feasibility of a finite element model as an ideal research tool for human maxillofacial gunshot wounds.Methods:Mandible CT scan data on the Chinese Visible Human were imported into MIMICS software to obtain the surface mesh of the mandible.Then,these surface-meshed models were imported into ANSA software for automatic net generation.Elements and nodes were partitioned on the basis of the mesh to obtain a three-dimensional finite element model for the mandible with every internal parameter consistent with those of our previously developed model in the pig mandible.The finite element model was imported into LS-DYNA for computation.Finally,the LS-POST was used to complete the simulation and the measurements.Results:A three-dimensional finite element model was successfully established for gunshot wounds in the human mandible.The stress distribution and the degree of injury were simulated dynamically for shots from two types of projectiles in the mandible at one entry angle and at three impact velocities.Conclusion:Three-dimensional finite element models will become ideal research tools for treatment of ballistic wounds of the human maxillofacial region.Using this human mandibular model as a foundation,we will be able to successfully develop three-dimensional finite element models for human maxillofacial gunshot wounds.0|42|5Updated：2026-03-12
- Abstract：Objective:To summarize and analyze the clinical and histopathological features of chronic acalculous cholecystitis （CAC） and to investigate the diagnosis and surgical treatment of chronic acalculous cholecystit.Methods:The study subjects were 39 patients with chronic biliary symptoms but no evidence of stones in the gallbladder by B ultrasonography and magnetic resonance cholopancreatography （MRCP） （CAC group）.The CCC group consisted of 66 patients taken randomly from concurrent all patients of chronic calculous cholecystitis （CCC）.All patients accepted fibergastroscopy,B ultrasonography,MRCP,laboratory examination preoperatively.We retrospectively analyzed the clinical features,B ultrasonography and MRCP findings,histopathological results and clinical outcomes between the two groups.Results:All the 39 patients were diagnosed by clinical symptoms,B ultrasonography,fatty meal gallbladder contractability studies under ultrasound,fibergastroscopy and magnetic resonance cholangiopancreatography （MRCP）,what’s more,they were pathologically verified postoperatively.In all patients,there was a complete absence of gallbladder wall contractability.Mucosa epithelial defect was found in 21 patients in CAC group （53.8%） and 16 patients in CCC group （24.2%） respectively （P<0.005）.Thickened arteriole wall was found in 29 patients in CAC group （74.4%） and none patient in CCC group （P<0.0001）.Thickened gallbladder wall （4 mm or more in thickness） was found in 33 patients in CAC group （84.6%） and 28 patients in CCC group （42.4%） respectively （P<0.005）.Bile stasis was found in 23 patients in CAC group （59.0%） and 14 patients in CCC group （21.2%） respectively by ultrasonography preoperatively and confirmed in operation （P<0.005）.The outcomes of cholecystectomy,expressed as total or near total relief,was similar in the two groups.No statistically significant differences were observed between patients with CAC （90%） and CCC （80%）,the P-value >0.05.Conclusion:Chronic acalculous cholecystitis could be diagnosed by symptoms,ultrasound,fatty meal gallbladder contractability studies under untrasoundand MRCP.The optimal treatment of chronic acalculous cholecystitis characterized by thickened arteriole wall and mucosa epithelial defect is cholecystectomy.0|14|7Updated：2026-03-12
- Abstract：Objective:To investigate the occupational protection status of clinical nursing staff vocationally exposed to anti-tumor drugs.Methods:A self-designed questionnaire was used to survey 180 clinical nursing staff vocationally exposed to anti-tumor drugs.Results:Recognition of the need for protection and dependent occupational protection behaviors were very poor in clinical nursing staff vocationally exposed to anti-tumor drugs.The management of the occupational protection of clinical nursing staff vocationally exposed to anti-tumor drugs was also seriously underdeveloped.Conclusion:There is deficiency in the understanding and related protection practices of clinical nursing staff vocationally exposed to anti-tumor drugs in our hospital.The protection measures currently employed in medical practice are inadequate in virtually every aspect considered.It is recommended that all clinical nursing staff should receive full occupational protection training in these matters.The training must raise nursing staff’s awareness of the need for occupational protection and standardize their occupational protection behaviors to conform to "best practice" models.These "best practice" models should be quickly established and all staff made cognizant of them forthwith.In addition,where occupational protection systems are already in place,they should be improved to come into line with the new "best practice" models instigated.0|60|1Updated：2026-03-12
- Abstract：Objective:To report a case of anisometropic amblyopia reversal as a result of branch retinal vein occlusion （BRVO） occurring in the sound fellow eye.Methods:An adult patient with childhood anisometropic amblyopia was found to exhibit gradually visual acuity improvement in the amblyopic eye as the result of decreased visual acuity in the sound fellow eye.Results:Four years after the BRVO,the patient subsequently regained normal vision in the previously amblyopic eye.Conclusion:Visual plasticity is preserved in adults but may require special or stronger stimulation and possibly longer treatment time than during childhood.0|13|0Updated：2026-03-12
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