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      Volume 27 ， Issue 1 ， 2012

      • Farnesoid X receptor expression is reduced in human hepatocellular carcinoma

        Zhang Wenyu1, Chen Ping2, Zhao Yuanyin3, Lou Guiyu3 1Department of Endocrinology, People’s Hospital of Zhengzhou, Zhengzhou 450003, China 2Department of Hepatobiliary Surgery, Daping Hospital, Institute of Surgery Research, Third Military Medical University, Chongqing 400042, China 3Department of Biochemistry, College of Basic Medical Sciences, Third Military Medical University, Chongqing 400038, China
        Vol. 27, Issue 1, Pages: 1-9(2012)
        Abstract：Farnesoid X receptor （FXR, NR1H4） is a member of nuclear hormone receptor superfamily. Previously studies showed that FXR-/- mice spontaneously developed liver tumors when they aged, however, the relevance of which to human hepatocellular carcinoma （HCC） is unclear. The aim of this study is to observe whether FXR expression is also downregulated in HCC and discuss the mechanism of the reduced FXR expression in HCC. Expression of FXR and small heterodimer partner （SHP） was measured by real-time PCR and immunohistochemical technique. Effect of pro-inflammatory cytokines on expression of FXR and its promoter activity were determined in primary hepatocytes or HepG2 and Huh7 cell lines. Our results showed that expression of FXR and its target gene SHP in human HCC was strongly downregulated compared to the normal liver tissues. In addition, pro-inflammatory cytokines were able to decrease FXR expression by inhibiting the FXR promoter activity. In conclusion this work demonstrates FXR expression is strongly downregulated in human HCC, which may be caused by decreased FXR promoter activity, suggesting a potential role of FXR in human HCC development.  
          
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      • Methylation of the PCDH8 （Protocadherin-8） gene in gastric cancer

        Zhang Danjie, Che Xiangming, Zhao Wei, Liao Xinhua, Bi Tieqiang, Li Haijun Department of General Surgery, First Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an 710061, China
        Vol. 27, Issue 1, Pages: 10-19(2012)
        Abstract：Objective: To investigate the methylation status of the PCDH8 （Protocadherin-8） gene in gastric cancer tissues and find out the relationship between methylation status of the PCDH8 and clinicopathological features in gastric cancer patients. Methods: We first investigated the methylation status of the PCDH8 （Protocadherin-8） gene in 65 gastric cancer and detected aberrant promoter methylation in gastric cancers; and then analyzed he relationship between methylation status of the PCDH8 and clinicopathological status with SPSS 13.0 software. Results: We first investigated the methylation status of the PCDH8 （Protocadherin-8） gene in 65 gastric cancer and detected aberrant promoter methylation in 36 of 65 （55.4%） gastric cancers. There was no significant difference in the distribution of patients with methylation or unmethylation of PCDH8 in terms of age, sex, tumor size, distant metastasis, or TNM stage. Methylation of PCDH8 was significantly correlated to negative pathological lymph node metastasis （P=0.038） and tumor differentiation （P=0.01）. These two factors were proved to be of prognostic importance. Conclusion: Methylated PCDH8 seems to have a trend for worse prognosis in gastric cancer. However, a further large series of tumor samples and a longer follow-up period are required to elucidate its potential role.  
          
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      • A meta-analysis of tight versus conventional glycemia control in critically ill brain-injured adults

        Qi Lei, Wang Maode, Liu Xin, Wang Tuo, Xu Gaofeng, Li Qi, Li Ruichun Department of Neurosurgery, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an 710061, China
        Vol. 27, Issue 1, Pages: 20-37(2012)
        Abstract：Objective: To evaluate the benefits and risks of tight glycemia control （TGC） versus conventional glucose control （CGC） in critically ill brain-injured adults. Methods: We performed meta-analysis by systematically searching PubMed, EMBASE, OVID, ScienceDirect, Web of Science, CNKI, Wanfang Data, and CQVIP databases to retrieve RCTs in any languages. We used Review Manager to perform meta-analysis. Odds ratios （ORs） or weighted mean differences （WMDs） with 95% confidence intervals （CIs） were calculated in analyses. Results: Twenty-six RCTs with a total of 3,759 participants were included in this meta-analysis. In-hospital mortality showed significant dissimilarity between TGC and CGC groups with OR of 0.76 （95%CI 0.58, 0.99）. However, in terms of overall mortality and long-term neurological severity outcome, it didn’t show differences with ORs of 0.93 （95%CI 0.79, 1.10） and 1.15 （95%CI 0.96, 1.37）. There were also discrepancies in infection rate and ICU length of stay with OR of 0.51 （95%CI 0.42, 0.62） and WMD of -2.37 （95%CI -2.99, -1.74）. Significances were observed in hypoglycemia events with ORs of 6.24 （95%CI 4.83, 8.07） and 2.73 （95%CI 2.56, 2.91） using two methods. Conclusion: In critically ill brain injury, TGC did not show beneficial effects on reducing overall mortality and long term neurological outcome, but it increased the risk of hypoglycemia.  
          
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        Updated：2026-03-12

      • Gallbladder carcinoma with tumor thrombus in common bile duct: an unusual way of growing invasion

        Yang Xinwei, Yang Jue, Man Xiaobo, Zhang Baohua, Shen Feng, Wu Mengchao Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200433, China
        Vol. 27, Issue 1, Pages: 38-46(2012)
        Abstract：Objective: To summarize the experience of diagnosis and surgical treatment for a rare invasion manner of gallbladder carcinoma, which was combined with tumor thrombus in common bile duct （CBD）. Methods: Between February 2003 and January 2005, 3 patients with gallbladder carcinoma who were identified of tumor thrombus in common bile duct in surgical procedure were retrospectively analyzed. Results: Abdominal ultrasound and magnetic resonance cholangiopancreatography （MRCP） were used for preoperative diagnosis. All 3 patients were given radical operations, which were composed of cholecystectomy, resection of the extrahepatic biliary duct, cuniform hepatectomy of gallbladder bed, skeletonization of the hepatoduodenal ligament, hilar choledochojejunostomy, and clearance of tumor thrombus from biell renal carcinoma. The patient has been doing well without any evidence of recurrence or metastasis for 6 months.  
          
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      • The procedure of CASEVAC/MEDEVAC in UNMIS

        Wang Jiusheng Department of Health Service Management, Second Military Medical University, Shanghai 200433, China
        Vol. 27, Issue 1, Pages: 47-57(2012)
        Abstract：Considering the bad condition and shortage of medical resource in Sudan peacekeeping mission area, the author contrives the procedure of CASEVAC/MEDEVAC, including definition, request, authorization, operation and miscellaneous, and stipulates the responsibility of parties concerned. The aim is to ensure systematic, organized and timely evacuation of patients to the most suitable medical facility for each individual case,thereby to minimize the loss of lives and limbs.  
          
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      • Li Xungang1, Cui Xingang1, Zhang Dongxu1, Xu Danfeng1, Gao Yi1, Yin Lei1, Jiang Lei2, Li Yuli3, Chen Ming1 1Departments of Urology, Urology Center of PLA, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China 2Department of Dentistry, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China 3Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
        Vol. 27, Issue 1, Pages: 58-62(2012)
        Abstract：Synchronous bilateral multiple chromophobe cell renal carcinoma is rare; here we report a case diagnosed with bilateral renal multiple tumors complicated with a cyst in the right kidney. Retroperitoneal laparoscopic bilateral nephron sparing surgery was performed and there was no serious postoperative renal dysfunction. Pathological and immunohistochemical diagnoses of both tumors were chromophobe cell renal carcinoma. The patient has been doing well without any evidence of recurrence or metastasis for 6 months.  
          
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