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Volume ， Issue 4 ， 2007
- Abstract：<正>Objective:To discuss strategies and methods of normalization on how to deal with and ana- lyze data for different chips with the combination of statistics,mathematics and hioinformatics in order to find significant difference genes.Methods:With Excel and SPSS software,high or low density chips were analyzed through total intensity normalization（TIN）and locally weighted linear regression normalization （LWLRN）.Results:These methods effectively reduced systemic errors and made data more comparable and reliable.Conclusion:These methods can search the genes of significant difference,although normal- ization methods are being developed and need to be improved further.Great breakthrough will be obtained in microarray data normalization analysis and transformation with the development of non-linear technolo- gy,software and hardware of computer.0|19|0Updated：2026-03-12
- Abstract：<正>Objective:To investigate the neural electrophysiologieal activity underlying Chinese and Eng- lish Stroop tasks for Chinese English bilinguals.Methods:Event-related potentials（ERPs）were recorded in 14 Chinese bilinguals with a moderate command of English when they performed the Stroop task pre- sented in English words and Chinese characters,respectively.Results:In Chinese task version,it was found an increased positivity over bilateral front-polar regions on incongruent trials compared with congru- ent trials,followed by an increased negativity over fronto-central region and an increased positivity over occipital region.While in English task version,only the increased negativity was observed over fronto-cen- tral region,but with reduced amplitude and anterior distribution.Conclusion:This increased negativity was proposed as an index of the resolution processes of conflicting information in the incongruent situa- tion.The increased positivity over occipital region on Chinese incongruent trials may indicate visually rechecking effect for Chinese character.0|189|2Updated：2026-03-12
- Abstract：<正>Objective:To investigate a novel surgical method for multilevel cervical spondylotic myeIopa- thy（CSM）.Methods:Totally 21 patients with multilevel CSM undergoing a novel surgical procedure from April 2001 to January 2004 were analyzed retrospectively.All patients experienced anterior cervical decompression surgery in subsection,autograft fusion and internal fixation.Preoperative,immediate post- operative and follow-up image data,X-rays and semi-quantitative Japanese orthopaedics association（JOA） scores were used to evaluate the restoration of lordosis（Cobb’s angle）,intervertebral heights,the stabili- ty of the cervical spine and the improvement of neurological impairment.Results:Preoperative symptoms were markedly alleviated or disappeared in most of the patients.According to the JOA scores,the ratio of improvement in neurological function was 72.2%,including excellent in 9 cases（42.9%）,good in 7 cases （33.30%）,fair in 3 cases（14.3%）and poor in 2 cases（9.5%）.Immediate postoperative X-rays showed obvious improvements in lordosis and in the intervertebral height of the cervical spine（P<0.01）.There is no evidence of instrument failure during the mean follow-up period of 14.2 months（9-24 months, P>0.01）.Conclusion:Anterior cervical decompression in subsection,autograft fusion and internal fixa- tion is a rational effective method for the surgical treatment of multilevel CSM.0|15|3Updated：2026-03-12
- Abstract：<正>Objective:To compare laparoscopic gastrectomy and conventional surgery on the dissemina- tion and seeding of tumor cells.Methods:Intraoperative peritoneal lavage cytologic examination was per- formed in 65 patients with gastric cancer,during laparoscopic gastrectomy（n=34）and conventional surgery（n=31）.Cytology was examined twice,immediately after opening the peritoneal cavity and just before closing the abdomen.Saline was poured into the peritoneal cavity,and 100 ml fluid was retrieved after irrigation.Laparoscopic instruments were lavaged after surgery with 100 ml saline.Carbon dioxide （CO2）was derived through the trocar side orifice after pneumoperitoneum during laparoscopic gastrectomy and filtered through 100 ml saline.Cytologic examination of the filtrate was performed after the filtration process.Results:The incidence of positive cytology during laparoscopic surgery was 32.26% in the preop- erative Iavage and 22.58% in the postoperative lavage.The incidence of positive cytology during conven- tional surgery was 41.18%0 before lavage and 26.47% after lavage.Only one positive cytology was detect- ed in the CO2 filtrate gas.The incidence of positive cytology in the lavage of the instruments during laparo- scopic surgery was 6.45%.Conclusion:During gastric laparoscopic surgery,CO2 pneumoperitoneum does not affect tumor cell dissemination and seeding.In this study,laparoscopic techniques used in gastric can- cer surgery were not associated with a higher risk for intraperitoneal dissemination of cancer cells than the conventional surgery.0|19|1Updated：2026-03-12
- Abstract：<正>Objective:To evaluate the orthopedic effects of a new method to treat skeletal crossbite in the early mixed dentition.Methods:Twenty cases（5.8-7.5 years old）with skeletal crossbite were treated by bonding the bite plate combined with the face mask protracting the upper jaw.Cephalometric radio- graphs were taken and analyzed before and after treatments.Results:On average,in all 20 cases the max- illa was moved by 2.06 mm forward;the mandible was turned 2.45°downward and backward;the skeletal crossbites were corrected and the facial profiles were improved satisfactorily.The period of treatment was conducted for 1.7 months on average.Conclusion:A good effect can be achieved by bonding bite plate combined with the face mask protracting the upper jaw to treat skeletal crossbite in the early mixed denti- tion,which will benefit the craniofacial growth and the development of young children.0|18|0Updated：2026-03-12
- Abstract：<正>Objective:To investigate the effect of preoperative limited fluid resuscitation on the patients with traumatic shock.Methods:Eighty-nine patients with multiple injuries complicating with shock were treated in Changhai Hospital between January 2002 to October 2005 and were divided into 3 groups accord ing to the preoperative levels of systolic blood pressure（SBP）.SBP of group A and group B were about 70 and 80 mmHg,respectively;and the SBP of group C was over 90 mmHg.Results:（1）There was no sig- nificant difference in age,gender,and injury severity score（ISS）,initiated resuscitation time and initiated operation time among the 3 groups.Preoperatively,there was significant difference in the amount of fluid resuscitation and infused erythrocyte suspension among group A,B and C（1687±96 ml,2096±87 ml. 2976±93 ml,P<0.05;and 294±110ml,404±113 ml,7984±230ml,P<0.05）.（2）The hemoglobin level in group C（94±45 g/L）was lower than that in group A（110±22 g/L）and group B（103±24 g/L）（P<0.05）.However,there was no significant difference in the level of hemoglobin between group A and B.（3）There was no significant difference in the incidence of acute renal failure（ARF）among the 3 groups.The incidence of acute respiratory distress syndrome（ARDS）of group C（31.2%）was higher than that of group A（16.7%）and group B（18.2%）（P<0.05）.The mortality of group C（34.4%）was higher than that of group A（12.5%）and group B（12.1%）（P<0.05）.Conclusion:Preoperative limited resuscitation applied on patients with traumatic shock can reduce blood loss,incidence of ARDS and mor tality.0|11|2Updated：2026-03-12
- Abstract：<正>Objective:To evaluate the effect of diltiazem and lidocaine on arterial pressure or heart rate and the quality of extubation in patients undergoing uvulopalatopharyngoplasty.Methods:Sixty patients were randomly divided into 4 groups:In the control group patients were given saline;in the lidocaine group patients were given 1.0 mg/kg lidocaine;in the diltiazem group patients were given 0.2 mg/kg dilti- azem;and in the lidocaine plus diltiazem group patients were given 1.0 mg/kg lidocaine and 0.2 mg/kg dil- tiazem.These drugs were given 2 min before tracheal extubation.Values for SBP,DBP,and HR were recorded,on arriving at the operating room,immediately at the end of the surgery,at the time of injection of the study drugs,at trachealextubation,at 1 minand 5 min after extubation.The quality ofextubation according to the Sebel’s grading scale were compared among the 4 groups.Results:During extubation in the control group HR,SBP and DBP increased significantly when compared to baseline levels.Both lido- caine（1.0 mg/kg）and diltiazem（0.2 mg/kg）successfully alleviated these increases.The suppressive ef- fect of diltiazem was greater than that of lidocaine.The combinative use of the two drugs minimized the in- creases.The administration of lidocaine significantly suppressed bucking or coughing compared with the other groups.Conclusions:The pressor responses and tachycardia occurring in patients with uvu- lopalatopharyngoplasty during emergence from anesthesia and tracheal extubation,can be easily blocked by a bolus dose of 1.0 mg/kg lidocaine,0.2 mg/kg diltiazem or the combinative use of the two drugs.And the concurrent use of lidocaine and diltiazem alleviated the hemodynamic changes more obviously.0|25|1Updated：2026-03-12
- Abstract：<正>Objective:To observe the feasibility and safety of awake anesthesia for tumor excisions in pa- tients with brain tumors involving cerebral functional areas.Methods:Fifty patients with brain tumors in- volving cerebral functional areas,ASAⅠ-Ⅱgrade,were enrolled in this study.Propofol and remifentanil were used for total intravenous anesthesia,and a laryngeal mask airway（LMA）was inserted for the air- way opening and synchronized intermittent mandatory ventilation（SIMV）.At the surgeon’s request for an intraoperative wake-up test,the propofol infusion was stopped advance of 10-15 min,the remifentanil in- fusion rate was decreased to 0.050-0.075μg/kg from 0.10-0.20μg/kg per min for easing surgical pain. The LMA was removed until the patient awakened.The anesthesiologist then kept up an on-going neuro- logical examination.After that,anesthesia was re-deepened and LMA was re-inserted until the whole surgery was accomplished.Results:Forty-six of 50 patients（92%）were successfully awakened and 4 （8%）failed to complete the intraoperative wake-up test because of dyspnea,over-sedation,or severe hy pertension.No severe complications occurred during the whole process.Conclusions:During the awake anesthetic period,the intraoperative wake-up test combined with navigation,evoked potential and ultra- sound techniques can help surgeons excise maximumly and precisely the brain tumors near to or in the functional areas.0|21|0Updated：2026-03-12
- Abstract：<正>Objective:To evaluate the effectiveness of endovenous laser therapy and conventional thera- py on the varicose of great saphenous vein.Methods:Thirty-two patients received endovenous laser thera- py and 32 patients were operated by conventional therapy（high ligation and stripping）.The observation results of great saphenous vein（GSV）were recorded by clinical evaluation and duplex ultrasound examina- tion.And the operating time,intraoperative blood loss,time to become moveable,duration of hospitaliza- tion and degree of feeling pain were compared between the two groups.Results:Compared with conven- tional therapy,laser therapy had good curative effect with less complications and no scars and no pains. There were significant differences between the two groups（P<0.01）.Conclusion:Laser therapy for varicose of great saphenous vein is better than the conventional therapy.It deserves to be widely used in clinical treatment.0|19|0Updated：2026-03-12
- Abstract：<正>Objective:To evaluate effects of diagnostic tests for Helicobacter pylori（H.pylori）infec- tion.Methods:A meta-analysis was conducted in 22 identified studies through Chinese literature searching which were published after 1995 and evaluated diagnostic tests for Helicobacter pylori（H.pylori）infec- tion.Results:Polymerase chain reaction（PCR）had the best performance with diagnostic odds ratio （DOR）of 6.7（5.5-7.8）,followed by 13C urea breath test and Enzyme-linked immunosorbent assay （ELISA）quantitative serological test,with DOR being 6.4（5.4-7.4）and 4.5（3.8-5.2）,respectively. Conclusion:Non-invasive tests are the appropriate methods for screening H.pylori infection,whereas in- vasive tests are the best methods for ascertaining the suspected patients.0|32|2Updated：2026-03-12
- Abstract：<正>Spinal cord injuries（SCI）usually result in impairment of axonal conduction and sensorimotor function.There are no effective therapy to completely repair SCI.Axonal demyelination is very common as a pathologic change in SCI,and demyelination partly contributes to neural function impairment.So,it may be reasonable that remyelination of demyelinated axons become one of effective therapeutic targets for SCI treatment. Demyelination involves myelin breakdown and loss of myelin-forming cells（oligodendrocytes）.The death of oligodendrocytes plays a key role in axonal demyelination in SCI.Recently a number of studies demonstrate that cell replacements could facilitate axonal remyelination and restore axonal conductive func- tion.Thus,it is expected that myelinogenetic cell transplantation（oligodendroglial lineage）will have good prospect as an effective therapy to improve axonal remyelination and restore neural function for SCI treat- ment in the near future.0|21|3Updated：2026-03-12
- Abstract：<正>Increasing cases of 9p syndrome have been reported since the first description in 1970.In the present case,a extra segment of the end of chromosome 9p resulting from a maternally inherited transloca- tion t（4;9）（q31;p24）was described in a liveborn boy with mental retardation and multiple congenital anomalies.The extra part of chromosome 9p includes segment of the chromosome region 4q31→qter of his mother but deletes a small segment 9p24→pter.To our knowledge,this is the first case described in a liveborn child.This paper also includes a review and tabulation of clinical features seen in the 34 reported cases.The new case had most characteristics reported cases besides worried face,fat and abnormal lower digestion tract,which is a modification and double expansion of the previous summarization on 9p syn- drome.0|21|1Updated：2026-03-12
- Abstract：<正>Objective:To evaluate a better method for the outcome of achalasia between laparoscopic Heller procedures（LHP）with partial fundoplications and thoracoscopic procedures（TP）.Methods: Eighty patients with achalasia were treated by LHP with partial fundoplications and another 120 cases re- ceived TP treatment.All the patients were from the First and Second Hospital of Xi’an Jiaotong Universi- ty.Their clinical information including dysphagia after surgery,operation time,staying in hospital,ab- normal gastroesophageal reflux and pH assay were recorded.Results:Achalasia treated by LHP with par- tial fundoplications can make a higher outcome remission rate compared to TP.Conclusion:LHP with par- tial fundoplications is better than TP.It is an ideal surgery for achalasia up to now.0|23|0Updated：2026-03-12
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