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  • RESEARCH

    Reporting on the latest research in epilepsy, a neurological disorder marked by recurrent seizures, experts have delved into the bio-physical mechanisms of epileptic seizures. By analyzing spontaneous and stimulation-induced seizures from patients with focal epilepsy, they isolated the slow-varying direct current (Sv DC) component, a frequency range often overlooked in electroencephalography. This component, which accounts for a high energy proportion in both ictal and interictal states, showed spatially dynamic changes and a moderate correlation with high-frequency activity. Notably, interictal Sv DC fluctuations were more pronounced in electrodes within the epileptogenic zone, suggesting its potential as a marker for epileptogenic localization. The temporal variability of the Sv DC signal also demonstrates potential as an early indicator of seizure development. This research provides a comprehensive framework for understanding epileptic networks and guiding diagnosis and therapy.

    Kui-Ying Yin, Tao Yu, Chuan Liu, Jin-Rong Yin

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:epilepsy;Epileptic seizures;Slow-varying direct current (Sv DC) field;Local voltage difference;Epileptogenic zone   
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  • RESEARCH

    In the field of acute liver injury (ALI) research, experts have identified a molecular mechanism that initiates and sustains liver regeneration through muscle-liver crosstalk via the FGF6-FGFBP1/FGF5 axis, providing a potential therapeutic target and treatment strategy for ALI.

    Yue-Jie Xu, Cai-Zhi Liu, Ying Chen, Lan-Xin Li, Bo Xu, Ling-Xin You, Mei-Yao Meng, Xin Li, Hong Zhang, Qiu-Rong Ding, Rong Zhang, Xin-Ran Ma, Xiao-Hua Chen, Cheng Hu

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Acute liver injury (ALI);Liver regeneration;Skeletal muscle;Fibroblast growth factor 6 (FGF6);Fibroblast growth factor binding protein 1 (FGFBP1)   
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  • RESEARCH

    In the field of tumor PANoptosis, a "boiling-bubbling" strategy is developed, introducing its research progress. Expert xx established the NZCB NPs system, which provides solutions to solve highly immunogenic tumor PANoptosis problems, laying a foundation for the construction of nano-catalytic oxidation system.

    Xuan-Shou Xu, Wei-Wei Ren, Heng Zhang, Dong-Liang Huo, Qi Lyu, Mei-Xiao Zhan, Hui-Xiong Xu, Li-Ying Wang, Min-Feng Huo, Jian-Lin Shi

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Piezoelectric nanocatalyst;Tumor PANoptosis;Sonodynamic therapy;Immunotherapy;Mesopore engineering   
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  • RESEARCH

    In the field of organ transplantation, a novel CRISPR-based detection platform was developed, establishing a one-pot RPA-CRISPR reaction system and optimizing it for BKV and JCV detection. This platform can simultaneously and rapidly detect BKV and JCV with high sensitivity, providing absolute quantification, which is suitable for viral load detection and conducive to personalized and precise treatment for organ transplant recipients.

    Yu Liu, Jing-Song Xu, Li Cao, Shuang Yang, Tian-Ming Li, Hai-Qian Huang, Jun-Heng Zhang, Xue Zhao, Qian Liu, Shun Li, Min Li, Hua Wang

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:BK virus (BKV);JC virus (JCV);kidney transplantation;Clustered regularly interspaced short palindromic repeats (CRISPR);Microfluidic;Lateral flow assay (LFA)   
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  • REVIEW

    Magnetic particle imaging (MPI), a novel imaging technique with high sensitivity and temporal resolution, is expected to become a mainstream technology for early diagnosis of brain diseases. This review explores its potential applications in brain diseases and discusses the prospects for diagnosis and management.

    Li-Shuang Guo, Yu An, Ze-Yu Zhang, Chen-Bin Ma, Jia-Qian Li, Zhen Dong, Jie Tian, Zhen-Yu Liu, Jian-Gang Liu

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Magnetic particle imaging;Brain diseases;Early diagnosis   
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  • REVIEW

    Recent advances in next-generation sequencing and bioinformatics have driven growing interest in the distinct roles of intratumoral microbiota, particularly intracellular bacteria, during tumor evolution. The present review explores the sources, mechanisms of invasion into cancer cells, and potential survival strategies of intracellular bacteria in neoplasms, highlighting their critical role in cancer development. Expert xx established the xx system, which provides solutions to solve xx problems and lay a foundation for the construction of xx system.

    Yi-Chen Luo, Xiu-Ting Huang, Rui Wang, Yu-Jing Lin, Jia-Xin Sun, Ke-Feng Li, De-Yun Wang, Yan Yan, Yong-Kang Qiao

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Intratumoral microbiome;Intracellular bacteria;Cancer progression;Immune modulation;Cancer therapeutics   
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  • REVIEW

    AI技术在骨科领域的应用进展。专家综述了AI在骨科临床和研究中的核心概念、历史演变、机器学习和深度学习框架,以及图像分析、疾病诊断、治疗等应用,为骨科AI技术的发展提供解决方案。

    Jian Song, Guang-Chao Wang, Si-Cheng Wang, Chong-Ru He, Ying-Ze Zhang, Xiao Chen, Jia-Can Su

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Artificial intelligence (AI);Orthopedics;Machine learning (ML);Deep learning (DL);Diagnostic;Therapeutics   
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  • LETTER TO THE EDITOR

    In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to solve xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.

    Ya-Le Jiang, Guo Zhao, Shu-Hang Wang, Ning Li

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Artificial intelligence (AI);Precision medicine;Standard of care   
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  • COMMENTARY

    In the field of xxx, expert xx has made significant research progress. By establishing the xx system/exploring the xx topic/verifying the xx conjecture, xx has provided solutions to address xx problems/open up a new direction for xx research/lay a foundation for the construction of the xx system.

    Ben H. Chew

    Military Medical Research Vol.12 , Issue 12 , (2025)
    Keywords:Miniaturized percutaneous nephrolithotomy (mPCNL);Minimally invasive percutaneous nephrolithotomy(mini PCNL);Nephrolithiasis;Stone   
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