High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
RESEARCH|Updated:2025-12-13
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High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
“In the field of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), experts have verified the conjecture that high-salt diet (HSD) consumption promotes the differentiation of CD4+ T cells to proinflammatory T helper 17 (Th17) cells, which aggravates CP/CPPS. This finding provides a potential therapeutic target for CP/CPPS.”
Military Medical ResearchVol. 12, Issue 10, Pages: 1501-1519(2025)
Affiliations:
1.Department of Urology, the First Affiliated Hospital of Anhui Medical University, Institute of Urology, and Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei 230022, China
2.Department of Urology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3.Department of Urology, Southern University of Science and Technology Hospital, Shenzhen 518055, Guangdong, China
4.Center for Scientific Research of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China