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High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
RESEARCH | Updated:2025-12-13
    • High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation

    • In the field of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), experts have verified the conjecture that high-salt diet (HSD) consumption promotes the differentiation of CD4+ T cells to proinflammatory T helper 17 (Th17) cells, which aggravates CP/CPPS. This finding provides a potential therapeutic target for CP/CPPS.
    • Military Medical Research   Vol. 12, Issue 10, Pages: 1501-1519(2025)
    • DOI:10.1186/s40779-025-00607-1    

      CLC:
    • Received:14 August 2024

      Accepted:11 April 2025

      Online First:19 May 2025

      Published:2025-10

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  • Jing Chen, Rui Feng, Bin-Bin Gong, et al. High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation[J]. Military Medical Research, 2025, 12(10): 1501-1519. DOI: 10.1186/s40779-025-00607-1.

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