RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

Yi-Qun Li; Fang-Zhou Sun; Chun-Xiao Li; Hong-Nan Mo; Yan-Tong Zhou; Dan Lv; Jing-Tong Zhai; Hai-Li Qian; Fei Ma

doi:10.1186/s40779-023-00470-y

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

RESEARCH | 更新时间：2025-12-13

- RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
- RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
- “在三阴性乳腺癌症脑转移领域，研究人员已经确定并验证了视黄酸受体反应器2（RARES2）在TNBC脑转移中的特异性下调。研究发现，RARRES2缺乏通过脂质代谢重编程促进BCBrM，为BCBrM提供潜在的生物标志物或治疗靶点。”
- Yi-Qun Li ，Fang-Zhou Sun ，Chun-Xiao Li ，Hong-Nan Mo ，Yan-Tong Zhou ，Dan Lv ，Jing-Tong Zhai ，Hai-Li Qian ，Fei Ma
- MMR 2024年11卷第1期页码：34-49
- 作者机构：
  1.Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
  2.State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- 作者简介：
  * qianhaili@pumc.edu.cn,
  mafei@cicams.ac.cn
- 基金信息：
  This work was financially supported by the National Natural Science Foundation of China(82203185;82230058;82172875 and 82073094);the National Key Research and Development Program of China(2021YFF1201300;2022YFE0103600);the CAMS Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-014;2021-I2M-1-022;and 2022-I2M-2-001);the Open Issue of State Key Laboratory of Molecular Oncology(SKL-KF-2021-16);the Independent Issue of State Key Laboratory of Molecular Oncology(SKL-2021-16);the Beijing Hope Marathon Special Fund of Chinese Cancer Foundation(LC2020B14)
- DOI： 10.1186/s40779-023-00470-y
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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

DOI： 10.1186/s40779-023-00470-y

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