Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function

Ren-Qi Yao; Peng-Yue Zhao; Zhi-Xuan Li; Yu-Yang Liu; Li-Yu Zheng; Yu Duan; Lu Wang; Rong-Li Yang; Hong-Jun Kang; Ji-Wei Hao; Jing-Yan Li; Ning Dong; Yao Wu; Xiao-Hui Du; Feng Zhu; Chao Ren; Guo-Sheng Wu; Zhao-Fan Xia; Yong-Ming Yao

doi:10.1186/s40779-023-00462-y

您当前的位置：

首页 >

文章列表页 >

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

RESEARCH | 更新时间：2024-01-23

- Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function
- Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function
- “On January 23, 2024, a team of experts led by Guo-Sheng Wu, Zhao-Fan Xia from the School of Department of Burn SurgeryandRen-Qi Yao, Yong-Ming Yao from the School of Translational Medicine Research Centerpublished an article in the MMR, introduces its research progress in the field of sepsis immunotherapy. Experts identified HLA-DRlowS100Ahigh monocytes driving immunosuppression and verified S100A9 blockade reverses immune depression, providing a novel therapeutic strategy for sepsis management.”
- Ren-Qi Yao ，Peng-Yue Zhao ，Zhi-Xuan Li ，Yu-Yang Liu ，Li-Yu Zheng ，Yu Duan ，Lu Wang ，Rong-Li Yang ，Hong-Jun Kang ，Ji-Wei Hao ，Jing-Yan Li ，Ning Dong ，Yao Wu ，Xiao-Hui Du ，Feng Zhu ，Chao Ren ，Guo-Sheng Wu ，Zhao-Fan Xia ，Yong-Ming Yao
- MMR 2023年10卷第6期页码：778-797
- 作者机构：
  1.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  2.Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  3.Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Beijing 100730, China
  4.Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  5.Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  6.Department of Critical Care Medicine, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  7.Intensive Care Unit, Dalian Municipal Central Hospital Affiliated Dalian University of Technology, Dalian 116033, Liaoning, China
  8.Department of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  9.Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- 作者简介：
  *: drwuguosheng@sina.cn;
  xiazhaofan_smmu@163.com;
  c_ff@sina.com
- 基金信息：
  the Key Project of National Natural Science Foundation of China(82130062;82241062;81930057);National Key Research and Development Program of China(2022YFA1104604);the Key Project of Military Medical Innovation Program of Chinese PLA(18CXZ026;BLJ18J006);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-076)
- DOI： 10.1186/s40779-023-00462-y
  中图分类号：
- 稿件说明：
移动端阅览
DOI：
DOI：

AI导读
HTML全文
图( 6 ) 表( 0 )
参考文献
出版信息
数据统计

51

浏览量

10

下载量

0

CSCD

文章被引用时，请邮件提醒。

提交

工具集

BibTeX下载
Endnote下载
RefMan 下载
NoteExpress下载
NoteFirst下载

关联资源

Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options

Metabolic syndrome and risk of sepsis and sepsis-related mortality: evidence from two large prospective cohort studies

Endothelial barrier and sepsis: mechanisms and potential therapeutic strategies

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

DOI： 10.1186/s40779-023-00462-y

AI导读

HTML全文

图( 6 ) 表( 0 )

参考文献

出版信息

数据统计

摘要

Abstract

关键词

Keywords

references