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ARN como arquitecto del genoma: bucles G en la regulación de los G-cuádruplex

  • role： Contribute equally, First author同等贡献者, 第一作者
  • Affiliation：

    Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China

    Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China

Jie Wang12,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    Department of Urology, Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangzhou 518036, China

Zhao-Jie Lyu3,  
  • role： Contribute equally同等贡献者
  • Affiliation：

    Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China

Qi Zhang1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, China

  • Email：chocs@ha.org.hk
  • Introduction：* William C. Cho chocs@ha.org.hk
William C. Cho4*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China

    Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK

  • Email：dechao.feng@ucl.ac.uk
  • Introduction：De-Chao Feng dechao.feng@ucl.ac.uk
De-Chao Feng15*

resumen

palabra clave

G-cuádruplex;híbridos ARN-ADN;inestabilidad genómica;reparación del ADN;arquitectura de la cromatina

References

  1. 1..
    Varshney D, Spiegel J, Zyner K, Tannahill D, Balasubramanian S. The regulation and functions of DNA and RNA G-quadruplexes. Nat Rev Mol Cell Biol. 2020;21(8):459-74.
  2. 2..
    Hänsel-Hertsch R, Beraldi D, Lensing SV, Marsico G, Zyner K, Parry A, et al. G-quadruplex structures mark human regulatory chromatin. Nat Genet.2016;48(10):1267-72.
  3. 3..
    Sato K, Lyu J, van den Berg J, Braat D, Cruz VM, Navarro Luzón C, et al. RNA transcripts regulate G-quadruplex landscapes through G-loop formation. Science. 2025;388(6752):1225-31.
  4. 4..
    Jimenez-Sainz J, Mathew J, Moore G, Lahiri S, Garbarino J, Eder JP, et al. BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair. Elife.2022;11:e79183.
  5. 5..
    Greenhough LA, Liang CC, Belan O, Kunzelmann S, Maslen S, Rodrigo-Brenni MC, et al. Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Nature. 2023;619(7970):650-7.
  6. 6..
    Gregg SQ, Robinson AR, Niedernhofer LJ. Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease. DNA Repair (Amst).2011;10(7):781-91.
  7. 7..
    Xu H, Hurley LH. A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461(Pidnarulex). Bioorg Med Chem Lett. 2022;77:129016.
  8. 8..
    Wang E, Thombre R, Shah Y, Latanich R, Wang J. G-quadruplexes as pathogenic drivers in neurodegenerative disorders. Nucleic Acids Res.2021;49(9):4816-30.

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