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Biofísica de las crisis epilépticas: el papel de la diferencia local de voltaje

  • role： Corresponding author, Contribute equally, First author通信作者, 同等贡献者, 第一作者
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

  • Email：yinkuiying77@outlook.com
  • Introduction：* Kui-Ying Yin yinkuiying77@outlook.com
Kui-Ying Yin1*,  
  • role： Corresponding author, Contribute equally通信作者, 同等贡献者
  • Affiliation：

    Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

  • Email：yutaoly@sina.com
  • Introduction：Tao Yu yutaoly@sina.com
Tao Yu2*,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Chuan Liu1,  
  • Affiliation：

    Link Sense Laboratory, Nanjing Research Institute of Electronic Technology, Nanjing 210039, China

Jin-Rong Yin1

resumen

AntecedentesLa epilepsia es un trastorno neurológico caracterizado por crisis recurrentes debido a la actividad hiperexcitada de la red neuronal. Las manifestaciones varían ampliamente, desde sutiles alteraciones sensoriales hasta profundas alteraciones de la conciencia, dependiendo de las regiones cerebrales afectadas y su etiología subyacente. Explorar los mecanismos biofísicos de las crisis epilépticas tiene gran importancia para predecir y controlar la enfermedad.MétodosAnalizamos 45 crisis espontáneas registradas de 24 pacientes con epilepsia focal, así como crisis inducidas por estimulación de 2 pacientes adicionales. Un filtro Butterworth de paso bajo de segundo orden aisló el componente de corriente continua de variación lenta (Sv DC) (0.01–0.5 Hz), un rango de frecuencia frecuentemente pasado por alto en electroencefalografía. La proporción energética del componente Sv DC se calculó dividiendo su energía total por la energía total de la señal durante las crisis y en un período de 1 hora que incluye la crisis, permitiendo la comparación entre estados ictales e interictales.ResultadosEl componente Sv DC exhibió cambios dinámicos espaciales durante ambos períodos ictal e interictal y mostró una correlación moderada con la actividad de alta frecuencia. Además, representó una alta proporción de energía en ambos períodos, con datos de crisis que mostraron que el 80.82% de los electrodos tenían ≥ 60% de energía Sv DC. Notablemente, las fluctuaciones interictales de Sv DC fueron más pronunciadas en electrodos ubicados dentro de la zona epileptogénica, lo que sugiere su potencial como marcador para la localización epileptogénica. Además, la variabilidad temporal de la señal Sv DC, reflejada en su dispersión, demuestra su potencial como un indicador temprano del desarrollo de crisis.ConclusionesEl componente Sv DC puede reflejar diferencias locales de voltaje probablemente vinculadas a la actividad de los canales iónicos, contribuyendo potencialmente a la iniciación de crisis. El análisis combinado de Sv DC con componentes de baja y alta frecuencia ofrece un marco integral para comprender las redes epilépticas y guiar el diagnóstico y la terapia.

palabra clave

epilepsia;crisis epilépticas;campo de corriente continua de variación lenta (Sv DC);diferencia local de voltaje;zona epileptogénica

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