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Construindo "paredes" para impedir patógenos: neutrófilos desempenham um papel na reparação da matriz extracelular

  • role： First author第一作者
  • Affiliation：

    State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China

Feng-Ying Liao1,  
  • Affiliation：

    State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China

Zhen Wang1,  
  • Affiliation：

    State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China

Jian-Xin Jiang1,  
  • role： Corresponding author通信作者
  • Affiliation：

    State Key Laboratory of Trauma and Chemical Poisoning, Daping Hospital, Army Medical University, Chongqing 400042, China

  • Email：zengling_1025@tmmu.edu.cn
  • Introduction：* Ling Zeng zengling_1025@tmmu.edu.cn
Ling Zeng1*

Resumo

Palavras-chave

Neutrófilos produtores de matriz; Regulação circadiana; Função da barreira cutânea; Cicatrização de feridas; Sinalização TGF-β

References

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    Xu JQ,Zhang WY,Fu JJ,Fang XZ,Gao CG,Li C, et al. Viral sepsis: diagnosis, clinical features, pathogenesis, and clinical considerations. Mil Med Res.2024;11(1):78.
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    Zhou M,Liu YW,He YH,Zhang JY,Guo H,Wang H, et al. FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depres-sion after traumatic brain injury. Mil Med Res. 2024;11(1):20.
  3. 3..
    Vicanolo T,Özcan A,Li JL,Huerta-López C,Ballesteros I,Rubio-Ponce A, et al. Matrix-producing neutrophils populate and shield the skin. Nature.2025;641(8063):740-8.
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    Ryu S,Shin JW,Kwon S,Lee J,Kim YC,Bae YS, et al. Siglec-F-expressing neutrophils are essential for creating a profibrotic microenvironment in renal fibrosis. J Clin Invest. 2022;132(12):e156876.
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    Fischer A,Wannemacher J,Christ S,Koopmans T,Kadri S,Zhao J, et al.Neutrophils direct preexisting matrix to initiate repair in damaged tissues.Nat Immunol. 2022;23(4):518-31.
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    Xu H,Lotfy P,Gelb S,Pragana A,Hehnly C,Byer LIJ, et al. The choroid plexus synergizes with immune cells during neuroinflammation. Cell.2024;187(18):4946-63.e4917.

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