Anterior|Próximo

Co-enxertos derivados de células-tronco contribuem para a reconstrução da retina e a melhora da função visual em um modelo de rato com dano a laser

  • role： First author第一作者
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

Deepthi S. Rajendran Nair1,  
  • Affiliation：

    Departments of Physical Medicine and Rehabilitation, Ophthalmology, Anatomy, and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA

    Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA

Magdalene J. Seiler23,  
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

Juan Carlos Martinez-Camarillo14,  
  • Affiliation：

    Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA

    Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA

Yuntian Xue35,  
  • Affiliation：

    Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA

Ruchi Sharma6,  
  • Affiliation：

    Unit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD 20892, USA

Kapil Bharti6,  
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

Mark S. Humayun14,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Ophthalmology, USC Roski Eye Institute, University of Southern California, Los Angeles, CA 91030, USA

    USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA 90033, USA

  • Email：biju.thomas@med.usc.edu
  • Introduction：* Biju B. Thomas biju.thomas@med.usc.edu
Biju B. Thomas14*

Resumo

Palavras-chave

Terapia baseada em células-tronco;Organoides da retina;Dano retiniano por laser;Doença degenerativa da retina;Epitélio pigmentado da retina;Transplante da retina;Co-enxerto

References

  1. 1..
    Lin B,McLelland BT,Aramant RB,Thomas BB,Nistor G,Keirstead HS, et al. Retina organoid transplants develop photoreceptors and improve visual function in RCS rats with RPE dysfunction. Invest Ophthalmol Vis Sci.2020;61(11):34.
  2. 2..
    McLelland BT,Lin B,Mathur A,Aramant RB,Thomas BB,Nistor G, et al. Transplanted hESC-derived retina organoid sheets differentiate, integrate, and improve visual function in retinal degenerate rats. Invest Ophthalmol Vis Sci. 2018;59(6):2586-603.
  3. 3..
    Rajendran Nair DS,Zhu D,Sharma R,Martinez Camarillo JC,Bharti K,Hinton DR, et al. Long-term transplant effects of iPSC-RPE monolayer in immunodeficient RCS rats. Cells. 2021;10(11):2951.
  4. 4..
    Thomas BB,Lin B,Martinez-Camarillo JC,Zhu D,McLelland BT,Nistor G, et al. Co-grafts of human embryonic stem cell derived retina organoids and retinal pigment epithelium for retinal reconstruction in immunode-ficient retinal Degenerate Royal College of Surgeons rats. Front Neurosci.2021;15:752958.
  5. 5..
    Gandhi JK,Mano F,Iezzi R,LoBue SA,Holman BH,Fautsch MP, et al. Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation. PLoS ONE. 2020;15(1):e0227641.
  6. 6..
    Singh MS,Balmer J,Barnard AR,Aslam SA,Moralli D,Green CM, et al. Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion. Nat Commun.2016;7:13537.

Leia o texto completo

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website