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Alvo do sistema nervoso central e periférico para regular a homeostase óssea: mecanismos e terapias potenciais

  • role： First author第一作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Tong-Zhou Liang1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Zhe-Yu Jin1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Yue-Jun Lin1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Zi-Yi Chen1,  
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

Ye Li1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

  • Email：jiankunxu@cuhk.edu.hk
  • Introduction：* Jian-Kun Xu jiankunxu@cuhk.edu.hk
Jian-Kun Xu12*,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, Guangdong, China

  • Email：fan.yang@siat.ac.cn
  • Introduction：Fan Yang fan.yang@siat.ac.cn
Fan Yang3*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Musculoskeletal Research Laboratory of Department of Orthopaedics& Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Innovative Orthopedic Biomaterial and Drug Translational Research Laboratory, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, the Chinese University of Hong Kong, Sha Tin 999077, Hong Kong, China

    Areas of Excellence Centre for Musculoskeletal Degeneration and Regeneration, Sha Tin 999077, Hong Kong, China

  • Email：lingqin@cuhk.edu.hk
  • Introduction：Ling Qin lingqin@cuhk.edu.hk
Ling Qin124*

Resumo

O esqueleto é inervado por diferentes tipos de nervos e recebe sinais do sistema nervoso para manter a homeostase e facilitar a regeneração ou reparo. Embora o papel dos nervos periféricos e dos sinais na regulação da homeostase óssea tenha sido amplamente investigado, a relação íntima entre o sistema nervoso central e o osso ainda é menos compreendida, mas tornou-se um tema quente no campo ósseo. Nesta revisão, discutimos observações clínicas e estudos com animais que elucidam a conexão entre o sistema nervoso e o metabolismo ósseo, tanto intacto quanto após lesão. Primeiro, exploramos estudos mecanicistas que vinculam núcleos cerebrais específicos à homeostase óssea, incluindo o hipotálamo ventromedial, núcleo arqueado, núcleo paraventricular do hipotálamo, amígdala e locus coeruleus. Em seguida, focamos nas características da inervação óssea e nos subtipos de nervos, como nervos sensoriais, simpáticos e parassimpáticos. Além disso, resumimos as características moleculares e funções regulatórias desses nervos. Finalmente, incluímos abordagens translacionais disponíveis que utilizam a função nervosa para melhorar a homeostase óssea e promover a regeneração óssea. Portanto, considerar o sistema nervoso no contexto das interações neuromusculoesqueléticas pode aprofundar nossa compreensão da homeostase esquelética e do processo de reparo, beneficiando, em última análise, a tradução clínica futura.

Palavras-chave

Osteoporose;sistema nervoso central;núcleos cerebrais;fibra nervosa periférica;homeostase óssea

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