References
- 1..Bunne C,Roohani Y,Rosen Y,Gupta A,Zhang X,Roed M, et al. How to build the virtual cell with artificial intelligence: priorities and opportuni-ties. Cell. 2024;187(25):7045-63.
- 2..Yang T,Ma F,Qian H,Xu B. AI-driven construction of digital cell model.Innov Life. 2024;2(4):100102.
- 3..Karr JR,Sanghvi JC,Macklin DN,Gutschow MV,Jacobs JM,JrBolival B, et al. A whole-cell computational model predicts phenotype from geno-type. Cell. 2012;150(2):389-401.
- 4..Maritan M,Autin L,Karr J,Covert MW,Olson AJ,Goodsell DS. Building structural models of a whole mycoplasma cell. J Mol Biol.2022;434(2):167351.
- 5..Turner NC,Im SA,Saura C,Juric D,Loibl S,Kalinsky K, et al. Inavolisib-based therapy in PIK3CA-mutated advanced breast cancer. N Engl J Med.2024;391(17):1584-96.
- 6..Zitnik M,Li MM,Wells A,Glass K,Morselli Gysi D,Krishnan A, et al.Current and future directions in network biology. Bioinform Adv.2024;4(1):vbae099.
- 7..Katsoulakis E,Wang Q,Wu H,Shahriyari L,Fletcher R,Liu J, et al. Digital twins for health: a scoping review. NPJ Digit Med. 2024;7(1):77.
- 8..Moding EJ,Nabet BY,Alizadeh AA,Diehn M. Detecting liquid remnants of solid tumors: circulating tumor DNA minimal residual disease. Cancer Discov. 2021;11(12):2968-86.
- 9..Zhang YP,Zhang XY,Cheng YT,Li B,Teng XZ,Zhang J, et al. Artificial intelligence-driven radiomics study in cancer: the role of feature engi-neering and modeling. Mil Med Res. 2023;10(1):22.
- 10..Liu J,Shen Z,He Y,Zhang X,Xu R,Yu H, et al. Towards out-of-distribution generalization: a survey. arXiv, 2021:2108.13624.

