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Associação entre doença periodontal e doenças sistêmicas: uma análise transversal das evidências atuais

  • role： First author第一作者
  • Affiliation：

    Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

Di Huang1,  
  • Affiliation：

    Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

Yun-Yun Wang1,  
  • Affiliation：

    Center for Evidence-Based and Trans-lational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Bing-Hui Li2,  
  • Affiliation：

    Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

Lan Wu3,  
  • Affiliation：

    Henan Provincial Engineering Research Center for Microecological Regulatory of Oral Environment and Oral Implantology, Kaifeng University Health Science Center, Kaifeng 475000, Henan, China

Wen-Zhong Xie4,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Stomatology, Daping Hospital, Army Medical University, Chongqing 400042, China

  • Email：zhoux20020549@163.com
  • Introduction：* Xia Zhou zhoux20020549@163.com
Xia Zhou5*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China

    Research Center for Medical Device Regulatory Science, Lanzhou University, Lanzhou 730000, China

  • Email：mab@lzu.edu.cn
  • Introduction：Bin Ma mab@lzu.edu.cn
Bin Ma16*

Resumo

BackgroundNumerous systematic reviews and meta-analyses have been published that evaluate the association between periodontal disease and systemic diseases, many of which address similar topics. Moreover, their quality requires assessment. Therefore, we performed a cross-sectional analysis to examine the evidence on the relationship between periodontal disease and systemic diseases.MethodsThe PubMed, Embase, Web of Science, and the Cochrane Library databases were systematically searched to identify relevant systematic reviews and meta-analyses. Only studies that considered periodontal disease as the exposure factor and various systemic diseases as the outcome were included. The basic characteristics and per-tinent data from the selected studies were extracted. The modified version of A Measurement Tool to Assess System-atic Reviews 2 (AMSTAR 2) was employed for quality assessment, while R software was used for statistical analysis.ResultsAmong the 212 relevant systematic reviews and meta-analyses, 57 were finally included in our analysis. These studies involved 75 diseases and 81 disease-related outcomes, with cancer (19/81) being the most frequently addressed topic. Of the 81 outcomes, 67 demonstrated a significant association. Notably, the highest risk estimate was found for head and neck cancer [odds ratio (OR) = 3.17, 95% confidence interval (CI) 1.78 − 5.64], while the low-est was observed for premature rupture of the amniotic sac [relative risk (RR) = 1.10, 95% CI 1.08 − 1.12]. The meth-odological quality ratings indicated that approximately 71.93% of included studies were classified as "Critically low" , with another 17.54% rated as "Low" , and only about 10.53% categorized as "Moderate" .ConclusionsPeriodontal disease significantly elevates the risks associated with 15 cancer-related, 8 cardiovascular-related, 8 metabolic-related, and 5 neurological-related outcomes. However, the overall methodological quality of existing systematic reviews and meta-analyses is generally suboptimal and requires enhancement to generate higher-quality evidence in the future.

Palavras-chave

Periodontal disease;Periodontitis;Cancer;Cardiovascular diseases;Metabolic disorders;Neurological conditions;Evidence analysis

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