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Complexo mitocondrial I: a chave para a ativação sustentada da microglia e manutenção da neuroinflamação

  • role： First author第一作者
  • Affiliation：

    Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China

Hua Wang1,  
  • Affiliation：

    Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China

Sheng-Yuan Yu2,  
  • Affiliation：

    Department of Biology, University of Copenhagen, 2100 Copenhagen O, Denmark

Sofus Nielsen3,  
  • role： Corresponding author通信作者
  • Affiliation：

    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

  • Email：wangxing@iccas.ac.cn
  • Introduction：* wangxing@iccas.ac.cn
Xing Wang4*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Department of Biomaterials, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan 250012, China

  • Email：zhaoweiwei@sdu.edu.cn
  • Introduction：zhaoweiwei@sdu.edu.cn
Wei-Wei Zhao5*

Resumo

Palavras-chave

Mitochondrial complex I;Neuroinflammation;Multiple sclerosis;Reverse electron transport;Microglial activation

References

  1. 1..
    Peruzzotti-Jametti L, Willis CM, Krzak G, Hamel R, Pirvan L, Ionescu RB, et al. Mitochondrial complex I activity in microglia sustains neuroinflammation. Nature. 2024;628(8006):195–203.
  2. 2..
    Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, et al. Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages. Cell. 2016;167(2):457–70.e13.
  3. 3..
    Deczkowska A, Keren-Shaul H, Weiner A, Colonna M, Schwartz M, Amit I. Disease-associated microglia: a universal immune sensor of neurodegeneration. Cell. 2018;173(5):1073–81.
  4. 4..
    Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H. Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis. Brain. 2017;140(7):1900–13.
  5. 5..
    Billingham LK, Stoolman JS, Vasan K, Rodriguez AE, Poor TA, Szibor M, et al. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol. 2022;23(5):692–704.

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