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O papel emergente do Panx1 como um potencial alvo terapêutico para a dor crônica

  • role： Corresponding author, First author通信作者, 第一作者
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

  • Email：mabel.cummins@vanderbilt.edu
  • Introduction：* mabel.cummins@vanderbilt.edu
Mabel L. Cummins1*,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Skylar Wechsler1,  
  • Affiliation：

    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Grace Delmonte1,  
  • Affiliation：

    Department of Anesthesiology, Division of Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN 37212, USA

Joseph J. Schlesinger2

Resumo

Palavras-chave

Pannexin 1 (PANX1);Chronic pain;Neuropathic pain;Inflammation;animal model;Translation

References

  1. 1..
    Sherry TB, Roth CP, Bhandarker M, Hepner KA. Chronic pain among service members: using administrative data to strengthen research and quality improvement. RAND Corporation. 2021. .
  2. 2..
    Kotlińska-Lemieszek A, Żylicz Z. Less well-known consequences of the long-term use of opioid analgesics: a comprehensive literature review. Drug Des Devel Ther. 2022;16:251–64.
  3. 3..
    Xing Q, Cibelli A, Yang GL, Dohare P, Li QH, Scemes E, et al. Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain. Mil Med Res. 2024;11(1):27.
  4. 4..
    Woolf CJ, Ma Q. Nociceptors-noxious stimulus detectors. Neuron. 2007;55(3):353–64.
  5. 5..
    Lemes JBP, de Campos Lima T, Santos DO, Neves AF, de Oliveira FS, Parada CA, et al. Participation of satellite glial cells of the dorsal root ganglia in acute nociception. Neurosci Lett. 2018;676:8–12.
  6. 6..
    Neves AF, Farias FH, de Magalhães SF, Araldi D, JrPagliusi M, Tambeli CH, et al. Peripheral inflammatory hyperalgesia depends on P2X7 receptors in satellite glial cells. Front Physiol. 2020;11:473.
  7. 7..
    Lemes JBP, Malange KF, Carvalho NS, Neves AF, Urban-Maldonado M, Kempe PRG, et al. Blocking Pannexin 1 channels alleviates peripheral inflammatory pain but not paclitaxel-induced neuropathy. J Integr Neurosci. 2024;23(3):64.
  8. 8..
    Liu J, Xiao Q, Xiao J, Niu C, Li Y, Zhang X, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduct Target Ther. 2022;7(1):3.
  9. 9..
    Zhao Y, Yang Z. Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain. Exp Ther Med. 2018;16(4): 3082–8.
  10. 10..
    Percie du Sert N, Rice ASC. Improving the translation of analgesic drugs to the clinic: animal models of neuropathic pain. Br J Pharmacol. 2014;171(12):2951–63.
  11. 11..
    Chen X, Yuan S, Mi L, Long Y, He H. Pannexin 1: insight into inflammatory conditions and its potential involvement in multiple organ dysfunction syndrome. Front Immunol. 2023;14:1217366.
  12. 12..
    Luo Y, Zheng S, Xiao W, Zhang H, Li Y. Pannexins in the musculoskeletal system: new targets for development and disease progression. Bone Res. 2024;12(1):26.
  13. 13..
    Scemes E, Velíšek L, Velíšková J. Astrocyte and neuronal Pannexin1 contribute distinctly to seizures. ASN Neuro. 2019;11:1759091419833502.

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